Source: Michael R. McGowen, Lawrence I. Grossman
and Derek E. Wildman “Dolphin
genome
provides
evidence
for
adaptive evolution of nervous system genes and a molecular rate slowdown”
Proc
Biol
Sci.
2012
Sep 22;279(1743):3643-51. Epub 2012 Jun 27.
Source: Ze Zheng, Xiaohua Xu, Xuebao Zhang, Aixia Wang, Chunbin Zhang,
Maik Hüttemann, Lawrence I. Grossman, Lung Chi Chen, Sanjay
Rajagopalan, Qinghua Sun, Kezhong Zhang. “Exposure
to
ambient
particulate
matter
induces a NASH-like phenotype and impairs hepatic glucose metabolism in
an animal model” J Hepatol. 2012 Aug 15. doi:pii:
S0168-8278(12)00632-0. 10.1016/j.jhep.2012.08.009
Kraus P, Sivakamasundari V, Lim SL, Xing X, Lipovich L, Lufkin T. Making sense of Dlx1 antisense RNA.
Dev Biol. 2013 Apr 15;376(2):224-35. doi: 10.1016/j.ydbio.2013.01.035.
Epub 2013 Feb 8.
Saporta MAC, Shy BR, Patzko A, Bai Y, Pennuto M, Ferri C, Tinelli E,
Saveri P, Kirschner D, Crowther M, Southwood CM, Wu X, Gow A, Feltri
ML, Wrabetz L, Shy ME (2012) MpzR98C
arrests
Schwann
cell
development in
a mouse model of early-onset Charcot-Marie-Tooth 1B Brain,
135:2032-2047. PMC3381724.
Recent
Publications of Center
Faculty Members
Kosir MA, Jia H, Ju
D and Lipovich L (2013). Challenging
paradigms: Long non-coding RNAs in breast ductal carcinoma in situ
(DCIS). Front. Genet. 4:50. doi:
10.3389/fgene.2013.00050. More...
Kraus P,
Sivakamasundari V, Lim SL, Xing X, Lipovich L, Lufkin T. Making sense of Dlx1 antisense
RNA. Dev Biol. 2013 Apr 15;376(2):224-35. doi:
10.1016/j.ydbio.2013.01.035. Epub 2013 Feb 8. More...
Lipovich L, Tarca AL, Cai J, Jia H, Chugani HT, Sterner KN, Grossman
LI, Uddin M, Hof PR, Sherwood CC, Kuzawa CW, Goodman M, Wildman DE. Developmental Changes in the
Transcriptome of Human Cerebral Cortex Tissue: Long Noncoding RNA
Transcripts. Cereb. Cortex (2013) doi:
10.1093/cercor/bhs414. More...
Southwood CM,
Lipovich L, Gow A (2012) Tissue-Restricted
Transcription
from
a
Conserved
Intragenic CpG Island in the Klf1 Gene.
Biol Reprod, doi: 10.1095/ biolreprod.112.099879. PMC3509778. More...
Hüttemann, M., Lee, I., Malek, M.H. (2012) (-)Epicatechin maintains endurance
training adaptation in mice after 14 days of detraining.
FASEB Journal, in press
Lipovich L,
Johnson R, and Lin CY. MacroRNA
underdogs in a microRNA world. (invited review article) Biochimica et Biophysica Acta
1799: 597-615, 2010. More....
Laing S, Wang
G, Briazova T, Zhang C, Wang A, Zheng Z, Gow A, Chen AF, Rajagopalan S,
Chen LC, Sun Q, Zhang K. Airborne
particulate matter selectively activates endoplasmic reticulum stress
response in the lung and liver tissues. Am J Physiol Cell Physiol
299(4):C736-749, 2010. More....
News Archive
|
UPCOMING SEMINARS
May 15, 2014
Lynne Maquat , PhD
J.
Lowell Orbison Endowed Chair and Professor, Department of Biochemistry
and Biophysics, School of Medicine and Dentistry, University of
Rochester
"'Alu'-strious effects on human mRNA metabolism"
at noon in 3125 Scott Hall
May 29, 2014
Donald Conrad, PhD
Assistant Professor, Departments of Genetics and Pathology & Immunology, Washington University School of Medicine
"Genetic and genomic analyses of spermatogenic function"
at noon in 3125 Scott Hall
CENTER
ANNOUNCEMENTS
Leonard Lipovich, PhD, Associate
Professor of Molecular Medicine and
Genetics and of Neurology is a co-author of the paper "A Promoter Level
Mammalian Expression Atlas," which will appear in the March 27, 2014
issue of Nature. The work provides the first ever quantitative
definition of the complete set of human and mouse gene promoters at
single-base resolution. More...
Henry Heng, PhD, Associate Professor of Molecular Medicine and Genetics
and of Pathology is featured in an April 2014 article of Genetic
Engineering and Biotechnology News. For many years, cancer has
been viewed as a condition in which the progressive accumulation of
recurrent mutations leads, in time, to the malignant phenotype.
“However, sequencing data reveal that this is not the case,” says Dr.
Heng. More...
Alexander Gow, PhD, Professor of Molecular Medicine and Genetics and of
Neurology and of Pediatrics has published in Brain Sciences fall 2013,
titled 'Potential for Cell-Mediated Immune Responses in Mouse Models of
Pelizaeus- Merzbacher Disease.' More...
Genetic Counseling Graduate
Program
Webinar Open
House
Friday, October 25th, 2013 2:00-3:30 PM EDT:
Interested in becoming a genetic counselor?
Check
the
leaflet
for
more
info.
The Center is pleased to
announce that the Board of Governors of Wayne State University has
approved three of our outstanding Faculty Members for promotion to the
rank of Associate Professor with continuing tenure. We
applaud these Members for their dedication to research and education
excellence, and congratulate them for achieving a significant
milestone. The 2013 promotion and tenure recipients are:
Leonard
Lipovich,
Ph.D.
Associate Professor of Molecular Medicine & Genetics and of
Neurology
Lobelia
Samavati, M.D.
Associate Professor of Molecular Medicine & Genetics and of
Internal Medicine
Kezhong
Zhang, Ph.D.
Associate Professor of Molecular Medicine & Genetics and of
Immunology & Microbiology
Robert Skoff, Ph.D.,
Professor of Anatomy and Cell Biology, and Associate Member of CMMG,
has been appointed a member of the Cellular and Molecular Biology of
the Glia Study Section of the Center for Scientific Review of the
National Institutes of Health. Dr. Skoff will serve through June 30,
2019. More...
Leonard Lipovich,
Ph.D., Assitant Professor of Molecular Medicine and Genetics
has been selected to present his work on long non-coding ribonucleic
acids at the Gordon Conference on Human Genetics and Genomics, set for
July 7-12 at Bryant University, Smithfield, R.I. More...
George Grunberger, M.D.
has been elected vice president of the American Association of Clinical
Endocrinologists; he will also serve on the association’s executive
committee and the board of directors. Dr. Grunberger is an
affiliate member of the CMMG and former Director; in 2002 he founded
the Grunberger Diabetes Institute in Bloomfield Hills,
MI. More...
Assistant Professor of
Molecular Medicine and Genetics Leonard Lipovich, Ph.D., will present
his lab’s work at the Cambridge Healthtech Institute’s Bio-IT World
Conference and Expo 2013, speaking as part of the conference’s Track
Nine, Drug Discovery and Informatics. Dr. Lipovich will present “Beyond
ENCODE: Placing Long Non-Coding RNA Genes into Regulatory Networks for
Therapeutics” in a 25-minute invited talk Thursday. More...
Gerald Feldman, M.D.,
Ph.D., F.A.C.M.G., Professor of Molecular Medicine and Genetics, has
been elected president-elect of the American College of Medical
Genetics and Genomics. Dr. Feldman, director of Clinical Genetic
Services, will serve as president-elect through March 2015, when he
will become president of the college and hold that position through
2017. More...
Lobelia Samavati, M.D.,
F.C.C.P., Assistant Professor of Molecular Medicine and Genetics and
Internal Medicine, and Director of the WSU Sarcoidosis/Interstitial
Lung Disease Center, will use a $389,681 grant for her study, “The Role
and Regulation of MKP-1 in Sarcoidosis.” The grant from the National
Heart, Lung and Blood Institute is part of a larger overall $1,906,944
NIH grant. More...
Interested in becoming a
genetic counselor? Visit our open
house to learn more about the Wayne State University Genetic
Counseling Graduate Program.
Recent research conducted
by Center Assistant Professor Dr. Kezhong Zhang, has
discovered why people living in congested, urban environments
are at greater risk of developing metabolic disease. The
study focuses on air particulate matter, called PM 2.5, and its affects
on the liver. More information is available here.
Wayne State's Systems
Biology of Epilepsy Project, led by Jeffrey Loeb, MD,
PhD, Associate Director of the Center for Molecular Medicine and
Genetics and Professor of Neurology, has released three new, published
studies that could have a major impact on the treatment of epilepsy.
Find out more here.
Gregory Kapatos, PhD,
Professor of Molecular Medicine and Genetics and of Pharmacology and
Leonard Lipovich, PhD, Assistant Professor of Molecular Medicine and
Genetics and of Neurology have received the 2012 College Teaching Award
in the School of Medicine.
Michael Tainsky, PhD,
Professor of Oncology and of Molecular Medicine and Genetics and Derek
Wildman, PhD, Associate Professor of Molecular Medicine and Genetics
and of Obstetrics and Gynecology have received the 2012 Research
Excellence Award in the School of Medicine.
The Center would like to
welcome Dr. Samiran Ghosh. Dr. Ghosh, a biostatistician, will
be Assistant Professor of Family Medicine and Public Health Sciences
and of Molecular Medicine and Genetics. He comes from the Stony Brook
University School of Medicine in New York, where he worked on
several depression-based projects. He has also published a book titled,
"Bayesian Modeling in Bioinformatics."
The Center would like to introduce Erin
Carmany, MSCGC, who will be Assistant Professor of Molecular
Medicine and Genetics as well as Associate Director of the Genetic
Counseling graduate program. Ms. Carmany has served in the
graduate program since 2005 as a clinical instructor.
Dr.
Leonard Lipovich, Assistant Professor of
Genetics and Molecular Medicine and of Neurology, is determined to
prove genetic material once seen as "junk" to be of clinical
value. Dr. Lipovich's lab has already contributed
several articles to the Encyclopedia of DNA (ENCODE), an
international collaborative effort that is the follow-up to
the Human Genome Project. This work is putting Wayne
State University at the forefront of genome analysis, and bringing it
alongside high-profile researcher groups in the United States,
and Japan.
The Center welcomes Dr.
Roger Pique-Regi
as its newest faculty member. Dr. Pique-Regi is
the new Assistant Professor of Molecular Medicine and Genetics
and also with the Department of Clinical and Translational
Sciences. His lab focuses on the topic of genetic
instability, specifically finding the DNA sequences responcible for
gene expression and how genetic instability can lead to
disease. His lab also distributes two software packages,
CENTIPEDE and GADA, programs used for genetic
analysis.
Dr.
Maik
Hüttemann, who is Associate Professor of Molecular
Medicine and Genetics and also of Biochemistry and Molecular Biology,
has been selected to receive a 2012 President's Award for Excellence in
Teaching. Dr. Hüttemann will be presented with the award at
the Wayne State University Academic Recognition Ceremony held April 26
at the McGregor Memorial Conference Center, where he will receive a
citation and a cash award of $2,500.
Dr. Jeffrey A. Loeb,
Professor of Neurology and of Molecular Medicine and Genetics, and
Associate Director of the Center, has been selected to receive the 2012
Charles H. Gershenson Distinguished Faculty Fellowship. Dr.
Loeb will receive the Fellowship on July
1st, which includes a total of
$13,000 in funds for the next two years.
Monica
Uddin,
PhD,
Assistant
Professor of Molecular Medicine and Genetics and of Psychiatry and
Behavioral Neurosciences, has been awarded the 2012 Eli Robins, Samuel
Guze award for early career promise by the American Psychopathological
Association. More...
News Archive |
