Selected Publications

Heng HH , Stevens JB, Liu G, Bremer SW, Ye KJ, Reddy PV, Wu GS, Wang YA, Tainsky MA, Ye CJ. (2006) Stochastic cancer progression driven by non-clonal chromosome aberrations. Journal of Cellular Physiology 208: 461-472.

Heng HH , Bremer SW, Stevens J, Ye KJ, Miller F, Liu G, Ye CJ. (2006). Prospect: Cancer progression by non-clonal chromosome aberrations. J Cell Biochem. 98: 1424-1435 (featured by cover).

Heng HH ., Liu, G., Bremer, S. Ye, K.J., Stevens J., and Ye C.J. (2006). Clonal and non-cloal chromosome aberrations and genome variation and aberration. Genome 49: 195-204 (featured by cover).

Woodward KJ, Cundall M, Sperle K, Sistermans EA, Ross M, Howell G, Gribble SM, Burford DC, Carter NP, Hobson DL, Garbern JY, Kamholz J, Heng H , Hodes ME, Malcolm S, Hobson GM. (2005). Heterogeneous duplications in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and nonhomologous recombination. Am J Hum Genet . 77:966-87.

Roberts PC, Mottillo EP, Baxa AC, Heng HH , Doyon-Reale N, Gregoire L, Lancaster WD, Rabah R, Schmelz EM. (2005). Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model. Neoplasia 7:944-956.

Shen, K.C., Heng, H ., Wang, Y., Lu, S., Liu, G., Deng, C.H., Brooks , S.C. , and Wang, Y.A. (2005). ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development. Cancer research 65: 8747-8753.

Biliran H., Wang, Y., Banerjee, S., Xu, H, Heng, H., Thakur, A., Bolling, A., Sarkar, FH and Liao JD (2005). Overexpression of cyclin D1 promotors tumor cell growth and confers resistance to Cisplatin-mediated apoptosis in an elastase-myc transgene expression pancreatic tumor cell line. Clinical Cancer Research 11; 1075-6086 (cover and featured article).

Wu, XH., Avni, D., Li ,X., Zhao, Q., Lin,Y., Heng, H., and Livingston, D. (2004). SV40 T antigen interacts with Nbs1 to disrupt cellular replication control. Genes & Development 18: 1305-1316.

Derjuga A, Gourley TS, Holm TM, Heng HH , Shivdasani RA, Ahmed R, Andrews NC, Blank V . (2004). Complexity of CNC Transcription Factors as Revealed by Gene Targeting of the Nrf3 Locus. MCB 24: 3286-3294.

Heng, H H ., Goetze, S., Ye, C.J., Liu, G., Stevens, J.B., Bremer, S.W., Bode, J., Wykes, SM., and Krawetz, SA. (2004). Chromatin loops are selectively anchored using Scaffold/matrix attachment regions. J Cell Sci . 117: 999-1008 (featured article).

Heng, H.H.Q ., Stevens, J., Liu, G., Bremer, S.B. and Ye C.J. (2004). Imaging genome abnormalities in cancer research (invited review). Cell & Chromosomes 3:1

Beatty, B., and Heng, H.H. (2004). Gene mapping by Fluorescence in situ hybridization. In Meyer R ed Encyclopedia of Molecular Cell Biology and Molecular Medicine. Vol 5 p137-171. Wiley-VCH

Kolas, N.K., Yuan, L., Hoog, C., Heng, H.H.Q., Marcon, E.,, and Moens, P.B. (2003). Meiotic chromosome cores deficient in structural proteins SCP3 and SCP2 are capable of chromatin loop attachment with possible impaired specificity. Cytogent Genome Res (in press).

Heng, H.H.Q., Ye, C.J., Yang, FT., Ebrahim, S., Liu, G., Bremer, S., Thomas, MC., Ye. J., Chen, T.J., Tuck-Muller, C., Yu, J.W., Krawetz, SA., and Johnson, A (2003). Analysis of marker or complex chromosomal rearrangements present in pre-and postnatal karyotypes utilizing a combination of G-banding, SKY and FISH. Clinical Genetics 63: 358-367.

Bode, J., Goetze, S., Heng, HH., Krawetz, SA, and Benham, C. (2003). From DNA structure to gene expression: Mediators of nuclear compartmentalization and dynamics. Chromosome Res 11: 435-445.

Scherer, S et al, (2003). Human Chromosome 7: DNA Sequence and Biology. Science 300: 767-772.

Yang, LV., Heng, H.H., Wan, J.,, Southwood,C.M., Gow, A and Li, L. (2003) Alternate promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoisis and spermatogenesis. Developmental Dynamics. 228: 606-616.

Takeuchi, T., Heng, H.H.Q., Ye, C. J., Liang, S.B., Sonobe, H and Yuji Ohtsuki, Y. (2003). Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. Am J Pathology 163: 1395-1404.

Cheung, J., Wilson, MD., Zhang, J., Khaja R., MacDonal, JR., Heng, H.H.Q., Koop, B.F., and Scherer, SW. (2003). Recent segmental and gene duplications in the mouse genome. Genome Biology 4: R47.

Heng, H.H.Q (2002). High resolution FISH mapping using chromatin and DNA fiber. In: Beatty et al ed, FISH: A Practical Approach. p.77-92. Oxford University Press.

Shekhar, M.P.V., Lyakhovich, A., Visscher, D. W., Heng, H., and Kondrat, N. (2002). Rad 6 overexpression induces multinucleation, centrosome amplification, abnormal mitotic, aneuploidy, and transformation. Cancer Research 62: 2115-2124.

Dong, S., Leung, KKH., Pelling, A.L., Lee, PYT., Tang, A., Heng, HHQ., Tsui, L-C., Tease, C., Fisher, G., Stell, K.P., and Cheah, KSE (2002). Circling, deafness and yellow coat colour displayed by the chromosome 3 mouse mutant yellow submarine (Ysb) and light coat circling (Lcc). Genomics 79(6):777-84.

Schmid, C., Heng, H.H.Q., Rubin, C., Ye, C.J., and Krawetz, SA (2001). Sperm nuclear matrix of the PRM1-PRM2-TNP2 domain is independent of ALU methylation. Hum Mole Reproduction 7: 903-911.

Heng, H.H.Q., Krawetz, SK., Lu, W., Bremer, S., Liu, G., and Ye, C.J. (2001). Re-defining the chromatin loop domain. Cytogent Cell Genet 93: 155-161.

Ye, J., Lu, W., Moens, P., Liu, G., Bremer, S., Wang Y, Hughes, M., Krawetz, S., and Heng, H.H.Q. (2001). The combination of SKY and specific loci detection with FISH or Immunostaining. Cytogenetics and Cell Genetics 93: 195-202.

Heng, H.H.Q., Liu, G., Lu, W., Bremer, S., Ye C.J., Hughes, M., and Moens, P. (2001). Multicolor SKY painting of mouse meiotic chromosomes. Genome 44: 293-298.

Ding, B.C., Witt, T.L., Hukku, B., Heng, H., Zhang, L., and Matherly, L.H. (2001). Deletions and translocations of the reduced folate carrier gene are associate with profound loss of gene expression in methotrexate resistant K562 human erythroleukemia cells. Biochem. Pharmacol 61: 665-675.

Liu, G., Lu, W., Bremer, S., Hameister, H., Schreiner, B., Hughes, M., and Heng, H.H.Q. (2000). Spectral Karyotyping of Mouse Cell Line WMP2. Cytogenet Cell Genet 90: 271-274.

Lee DK, Lynch KR, Nguyen T, Im D, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng H.H.Q, Seeman P, George SR, O'Dowd BF, Marchese A. (2000). Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta 1490(3):311-323.

Heng, H.H.Q, Spyropoulos, B., Moens, PB (2000). DNA-protein in situ co-detection. Methods in Molecular Biology: In situ hybridization protocols. Vol: 123: 15-27. Clifton, New Jersey, Humana Press.

Heng, H.H.Q (2000). Released chromatin or DNA fiber preparation for high-resolution fiber FISH. Methods in Molecular Biology: In situ hybridization protocols. Vol: 123: 69-81. Clifton, New Jersey, Humana Press.