Professor (also with Karmanos Cancer Institute and Pathology);
Ph.D., Cornell, 1977. Cancer genetic studies of familial
cancers to determine the inherited cancer genes, analyze the
mechanism of their action, and factors affecting genetic
penetrance of the cancer phenotype.
Research Interests
The overall theme of the research within my laboratory is the understanding of basic mechanisms of molecular and cellular biology that are altered as cells progress to become neoplastic. My approach has been to use in vitro human cell models of carcinogenesis and differentiation to identify critical molecular mechanisms. We have identified studied spontaneous genomic instability immortalization in cells from familial cancer patients. In particular we are interested in mechanisms of transcription that cause changes in cell phenotype. We are developing novel cancer diagnostics methods for high risk populations who are genetically predisposed to cancer.
Selected Publications
Draghici S, Kulaeva O, Hoff B, Petrov A, Shams S, Tainsky MA. Noise sampling method: an ANOVA approach allowing robust selection of differentially regulated genes measured by DNA microarrays. Bioinformatics. 2003;19(11):1348-59.
Draghici S, Khatri P, Bhavsar P, Shah A, Krawetz SA, Tainsky MA. Onto-Tools, the toolkit of the modern biologist: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate. Nucleic Acids Res. 2003;31(13):3775-81
Kulaeva OI, Draghici S, Tang L, Kraniak JM, Land SJ, Tainsky MA. Epigenetic silencing of multiple interferon pathway genes after cellular immortalization. Oncogene. 2003;22(26):4118-27.
Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol. 2003;23(9):3173-85.
Search Pubmed:
See also: http://www.karmanos.org/~tainskym/
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