Cost of the War in Iraq
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Anton Scott Goustin, Assistant Professor; Ph.D., (University of California at Berkeley), 1979. Molecular basis of aging; SIR2-family of NAD+-dependent protein deacetylases (see cartoon above from Cynthia Wolberger's group at Johns Hopkins, modified), the dual-specificity phosphatases, cell polarity (PAR3/PAR6/aPKC, Cdc42, PI3K), metabolic oscillations, solitons, tesselation. The role of the AHSG (FETUA) genes in humans and rat in insulin resistance and metabolic syndrome. Waves, waves, waves.

My resume in a graphical-rich format.

Collaborative projects:
"Function of SIR2-related NAD+-dependent protein deacetylases in mice", Michael A. Tainsky, Ph.D., Chief Scientific Officer, Karmanos Cancer Institute. We have recently published a report describing the phosphorylation of SIRT2 and its role in control of mitotic exit and cytokinesis in the journal Molec. Cell. Biol. Putative orthologs of human SIRT2 have been identified in Drosophila, the Anopheles mosquito, the silkworm, zebrafish (Danio rerio), Xenopus, chickens, pigs, cattle, sheep, mouse, and humans. It may be possible to genetically dissect mitotic and cytokinetic control steps in early development, where a simple G2/M checkpoint system gives way to a more complicated pattern, as described by Bruce Edgar in fruit flies.

Mouse getting knocked out!

" Function of a natural insulin receptor tyrosine kinase inhibitor understood through the use of Ahsg knockout mice," Joseph C. Dunbar, Ph.D., Physiology, George Grunberger, M.D., and Suresh T. Mathews, Ph.D. Check out our recent paper in Molec. Cell. Endocrinol. demonstrating the first direct interaction of the activated insulin receptor with a2-HS-glycoprotein. Or this paper from Pia and Bo Ek on phosphorylation of human a2-HS-glycoprotein. Loss of fetuin or a2-HS-glycoprotein in a mouse makes a mouse much more sensitive to insulin and provides resistance to weight gain after feeding a high-fat diet. These results, published in the journal Diabetes in August 2002 provide the basis of a pending US patent.

We think we have defined the function of a gene whose protein product was first described in Nature by Kai Pedersen, using Nobelist Theodor Svedbergs (1884-1971) newly-invented ultracentrifuge to explore protein physical chemistry at Uppsala University in neutral Sweden during World War II. The AHSG-FETUA genes seem to have two mode of regulation. One is physiological, involving a fasting-feeding switch and the HNF transcription factors and the co-activator PGC-1. The second is pathological, and involves a change in the chromatin structure of the AHSG gene after prolonged feeding on a high-fat (HF) diet, disabling the full shut-off of the AHSG gene. Woltje et al have just published that there is a steroid response element in the mouse AHSG/FETUA gene at -146/-119 which mediates glucocorticoid-induced increased in AHSG mRNA.

  • "Antisense gene therapy of lymphoma," Ayad al-Katib, M.D., Division of Hem-Onc, Internal Medicine, Christine Chow, Ph.D., Department of Chemistry, Jean-Paul Desaulniers. Jean-Paul just was awarded his Ph.D. in Chemistry YAY! (July 14, 2005). The project was initiated with visiting researcher Nayera Hamdy el-Shakankiry, M.D. (National Cancer Institute, Cairo, Egypt); funded by an interdisciplinary grants program by the WSU Vice-President for Research in 1997 and was driven by Dr. el-Shakankiry who took the photo above (L, sheep red blood cells painted with GPI-linked minbody (ScFv) to CD20 rosette with CD20-positive lymphoma cells (L panel) but not with CD20-negative REL cells). The work is now in the Journal of Immunological Methods.
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    How cellular signaling fits into our understanding of genes, development, and evolution: the cyberbiology synthesis
    "Imaging EGFR-HER2 Heterodimerization Using GFP and FRET"
    With George Grunberger, M.D., Craig N. Giroux, Ph.D.,, based on the summer 1997 project of Mr. Garrett C Heffner.

    "Molecular events in mucosal transmission of HIV-1 (a collaborative project with Dr. R. A. Thomas)"
    This project involves Robert A Thomas, Ph.D, Sandy Bergh and Brandee Brewer, collaborators at Hutzel Hospital (Detroit Medical Center), the Danish Cancer Society (Aarhus, Denmark), and Stellenbosch University, Cape Town, South Africa. We are especially interested in understanding subtype differences in the transmission process, with a focus on the C subtype, very prevalent in southern Africa and in India. You may wish to visit theWWW page focused on the global HIV-1 epidemic, especially in sub-Saharan Africa.

    Representative Publications

    Mathews ST, Chellam N, Srinivas PR, Cintron VJ, Leon MA, Goustin AS, Grunberger G. (2000). Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor. Molec. Cell. Endocrinol. 164, 87-98.MEDLINE.
    Chi, K.D., McPhee, R.A., Wagner, A.S., Dietz, J.J., Pantazis, P., and Goustin, A.S. 1997. Integration of proviral DNA into the PDGF -receptor gene in HTLV-I-infected T cells results in a novel tyrosine kinase product with transforming activity. Oncogene 15(9), 1051-1058. August 28, 1997).

    Srinivas PR, Wagner AS, Reddy LV, Deutsch, DD, Leon MA, Goustin AS, Grunberger G. (1993). Serum 2-HS-glycoportein in is an inhibitor of the human insulin receptor at the tyrosine kinase level. Molec. Endocrinol. 7(11), 1445-1455.
    Srinivas PR, Goustin AS, Grunberger G. (1995). Baculoviral expression of a natural inhibitor of the human insulin receptor tyrosine kinase. Biochim. Biophys. Res. Commun. 208(2), 879-885.
    Srinivas PR, Deutsch DD, Mathews ST, Goustin AS, Leon MA, Grunberger G. (1996). Recombinant human 2-HS glycoprotein inhibits insulin-stimulated mitogenic pathway without affecting metabolic signaling in Chinese hamster ovary cells overexpressing the human insulin receptor. Cellular Signaling, 8(8), 567-573.
    The Hck kinase (left), an elegant structure of a Src-family member tyrosine kinase, published by John Kuriyan's group at Rockefeller University.

    Please click here to see what's going on in the lab this summer (1997), or click here to see what I think about peace and justice.
    If you don't care about either peace or justice, you probably do care about money. Here's how to get some funding for your research:
    You may send E-mail to: genetics.wayne.edu

    SNAIL MAIL/PHONE/FAX

    Anton-Scott Goustin, Ph.D.
    Center for Molecular Medicine and Genetics
    3135 Scott Hall
    Detroit, Michigan 48201-1928 USA
    PHONE 313-577-1627
    FAX 313-577-5218
    Right now in Detroit, the time is .
    The ski-run called Fang where I got in trouble with the Austrian army in January 2001

    When it is 88°F here in the geological well called Detroit with a dewpoint in the 60s, I can take solace in knowing that high up in the Andes, the air is fresh, the sky is clean, and...check out La Paz, Bolivia where most of the people speak Ketxua, as close to the language of the great Incas as modern Icelandic is to the language of the Vikings.