Fei Song, M.D., Ph.D.
Assistant Professor

3129 Elliman Building
421 E. Canfield Avenue
Detroit, MI 48201
Voice: 313-577-1375
FAX: 313-577-7552
Assistant Professor (also with Neurology); M.D., 1985 (China), Ph.D., 1995, Kyushu University, (Japan). Cellular and molecular Immunology.

Research Interests

Immunomodulation, immunotherapy, molecular signal pathway and targeted therapeutics in human neurological disorder diseases including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) as well as their animal models.

Selected Publications

Song F, Chiang P, Wang J, Ravits J, Loeb JA. Aberrant neuregulin 1 signaling in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 71:104-15, 2012.

Ma Z, Wang J, Song F, Loeb JA. Critical period of axoglial signaling between neuregulin-1 and brain- derived neurotrophic factor required for early Schwann cell survival and differentiation. J Neurosci. 31:9630-40, 2011.

Song F, Wardrop R, Gienapp I, Stuckman S, Meyer A, Shawler T, and Whitacre CC. The Peyer’s patch is a critical immunoregulatory site for mucosal tolerance in experimental autoimmune encephalomylelitis (EAE). J. Autoimmunity. 30:230-237, 2008.

McClain, M, N. Gatson, N. Damico, T. Papenfuss, I. Gienapp, F. Song, T. Shawler, & C. Whitacre. Pregnancy suppresses experimental autoimmune encephalomyelitis (EAE) through immunoregulatory cytokine production. J. Immunology. 179:8146-8152, 2007.

Song F, Guan Z, Gienapp I, Shawler T, Benson J, and Whitacre CC. The thymus plays a role in oral tolerance in experimental autoimmune encephalomyelitis (EAE). J. Immunology. 177:1500-1509, 2006.

Papenfuss, TL, Rogers CJ, Gienapp I, Yurrita M, McClain M, Damico N, Valo J, Song F, and Whitacre CC. Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains. J. Neuroimmunology, 150:59-69, 2004.

Song F, Gienapp I, Wang X, and Whitacre CC. Activation of V8 T cells affects spontaneous EAE in MBP TCR transgenic mice. J. Neuroimmunology, 123:112-122, 2002.

Song F, Wardrop R, Gienapp I, Stuckman S, Goverman J, and Whitacre CC. Differences between two strains of myelin basic protein (MBP) TCR transgenic mice: implications for tolerance induction. J. Autoimmunity, 18:27-37, 2002.

Song, F, and Whitacre CC. The role of the gut lymphoid tissue in induction of oral tolerance. Current Opinion in Investigational Drugs, 2:1382-6, 2001.

Song, F., Ito K, Denning TL, Kuninger DT, Papaconstantinou J, Gourley W, Klimpel GR, Balish E, Hokanson J, and Ernst PB. Expression of the neutrophil chemokine KC in colon of mice with enterocolitis and by intestinal epithelial cell lines: effects of flora and proinflammatory cytokines. J. Immunology. 162:2275-80, 1999.

Song, F., Matsuzaki G, Mitsuyama M, and Nomoto K. Differential effects of viable and killed bacteria on Interlukin-12 expression of macrophages. J. Immunology. 156:2979-84, 1996.


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