|Russell L. Finley, Jr., Ph.D.
Division Director of Basic Science Research
3212 Scott Hall
540 East Canfield
Detroit, MI 48201
|Professor (also with Biochemistry and Molecular Biology; Member, Karmanos Cancer Institute); Ph.D., SUNY Upstate Medical University, 1990. Regulatory networks that control cell proliferation; high throughput technologies to study gene and protein interaction networks.
Research in our laboratory follows two main themes. One is directed at understanding how regulatory networks control biological processes. Our approach is to identify and characterize networks of interacting genes and proteins using high throughput technologies, including the yeast two-hybrid system and RNAi screens. The interaction maps that we generate from these studies form the foundation for discovering and understanding cellular regulatory pathways. A second theme of our research is directed at understanding the molecular mechanisms that control cell division. For these studies we are using the genetically tractable model organism, Drosophila (the fruit fly). We are studying gene networks centered on two novel conserved cyclin proteins (named Cyclin Y and Cyclin J). Cyclin proteins are regulators of cyclin-dependent kinases (Cdks), which are highly conserved S/T protein kinases that control the cell division cycle in all eukaryotes. For more information see the Finley Lab website.
Murali T, Pacifico S, Yu J, Guest S, Roberts GG 3rd, Finley RL Jr. DroID 2011: A comprehensive, integrated resource for protein, transcription factor, RNA, and gene interactions for Drosophila. Nucleic Acids Res. 2011 Jan; 39: D736-43.
Guest ST, Yu J, Liu D, Hines JA, Kashat MA, Finley, Jr., RL. A protein network-guided screen for cell cycle regulators in Drosophila. BMC Syst Biol. 2011 May 6;5(1):65.
Liu D, Guest S, Finley RL Jr. "Why cyclin Y? A highly conserved cyclin with essential functions." Fly (Austin). 2010 Oct;4(4):278-82.
Liu, D., and Finley, Jr., R.L. "Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Genetics," 184: 1025-1035, 2010.
Schwartz, A.S., Yu, J., Gardenour, K.R., Finley, Jr., R.L., and Ideker, T. "Cost effective strategies for mapping the interactome." Nature Methods, 6: 55-61, 2009.
Yu, J., and Finley, Jr., R.L. Combining multiple positive training sets to generate confidence scores for protein-protein interactions. Bioinformatics, 25: 105-11, 2009.
Yu, J., Pacifico, S., Liu, G., and Finley, Jr., R.L. DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions. BMC Genomics, 9:461, pp1-9, (PMID: 18840285), 2008.
Parrish, J.R., Liu, G., Hines, J.A., Yu, J., Chan, J.E., Mangiola, B.A., Zhang, H., Pacifico, S., Fotouhi, F., DiRita, V.J., Ideker, T., Andrews, P., and Finley, Jr., R.L. A proteome-wide protein interaction map for Campylobacter jejuni. Genome Biology, 8(7) R130.1-19, 2007.
Pacifico, S., Liu, G., Guest, S., Parrish, J.R., Fotouhi, F., and Finley, Jr., R.L. A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics 7, 195, 2006.
Stanyon , C.A. , Liu, G., Mangiola, B.A., Patel, N., Giot, L., Kuang, B., Zhang, H., Zhong, J., and Finley, Jr.,R.L. A Drosophila protein interaction map centered on cell cycle regulators. Genome Biology 12, R96:1-14, 2004.
Zhong, J., Zhang, H., Stanyon , C.A. , Tromp, G., and Finley, Jr., R.L. A strategy for constructing large protein interaction maps using the yeast two-hybrid system: regulated expression arrays and two-phase mating. Genome Research, 13, 2691-2699, 2003.
Giot, L., Bader, J. S. , Brouwer, C., Chaudhuri, A., Kuang, B., Li, Y., Hao, Y. L., Ooi, C.E., Godwin, B., Vitols, E., Govindan, V., Pochart, P., Machineni, H., Welsh, M., Kong, Y., Zerhusen, B., Malcolm, R., Varrone, Z., Collis, A. Minto, M., Burgess, S., McDaniel, L., Stimpson, E., Spriggs, F., Williams, J., Neurath, K., Ioime, N., Agee, M., Voss, E., Furtak, K., Renzulli, R., Aanensen, N., Carrolla, S., Bickelhaupt, E., Lazovatsk, Y., DaSilva, A., Zhong, J., Stanyon, C.A., Finley, Jr., R.L., White, K.P., Braverman, M., Jarvie, T., Gold, S., Leach, M., Knight, J., Shimkets, R.A, McKenna, M.P., Rothberg, J.M., Chant J. A. A Genome-Scale Protein Interaction Map of Drosophila melanogaster. Science, 203, 1727-1736, 2003.
A role for Cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis. 2000. M.G. Kolonin and R.L. Finley Jr. Developmental Biology 227, 661-672. [Full text]
Kolonin, M.G., and Finley, Jr., R.L. Targeting cyclin-dependent kinases in Drosophila with peptide aptamers. Proc. Natl. Acad. Sci. U.S.A. 95:14266-14271, 1998.