Henry H. Q. Heng, Ph.D.
Associate Professor

3226 Scott Hall
540 E. Canfield
Detroit, MI 48201
Voice: 313-577-9544
FAX: 313-577-5218

Heng Laboratory @Wayne State University

Associate Professor (also with Karmanos Cancer Institute and Pathology); Ph.D., Toronto, 1994. Molecular cytogenetics; genome structure and function; genomic instability and cancer progression.

Selected Publications

G. Liu, J. B. Stevens, S. D. Horne, B. Y. Abdallah, K. J. Ye, S. W. Bremer, C. J. Ye, D. J. Chen and H. H. Heng.  "Genome chaos: Survival strategy during crisis," Cell Cycle, In press (2013).

B. Y. Abdallah, S. D. Horne, M. Kurkinen, J. B. Stevens, G. Liu, C. J. Ye, J. Barbat, S. W. Bremer and H. H. Heng.  "Ovarian cancer evolution through stochastic genome alterations: defining the genomic role in ovarian cancer," Syst Biol Reprod Med, In press (2013)

J. B. Stevens, G. Liu, B. Y. Abdallah, S. D. Horne, K. J. Ye, S. W. Bremer, C. J. Ye, S. A. Krawetz and H. H. Heng.  "Unstable genomes elevate transcriptome dynamics," Int J Cancer, In press (2013)

B. Y. Abdallah, S. D. Horne, J. B. Stevens, G. Liu, A. Y. Ying, B. Vanderhyden, S. A. Krawetz, R. Gorelick and H. H. Heng.  "Single cell heterogeneity: Why unstable genomes are incompatible with average profiles," Cell Cycle 12 (23), 3640-3649 (2013)

H. H. Heng.  "Genomics: HeLa genome versus donor's genome," Nature 501 (7466), 167 (2013).

H. H. Heng, S. W. Bremer, J. B. Stevens, S. D. Horne, G. Liu, B. Y. Abdallah, K. J. Ye and C. J. Ye.  "Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution," Cancer Metastasis Rev 32 (3-4), 325-340 (2013)

H. H. Heng, "Preface," Cancer Metastasis Rev 32 (3-4), 323-324 (2013)

J. B. Stevens, S. D. Horne, B. Y. Abdallah, C. J. Ye and H. H. Heng.  "Chromosomal instability and transcriptome dynamics in cancer," Cancer Metastasis Rev 32 (3-4), 391-402 (2013)

H. H. Heng.  "The contribution of genomic heterogeneity.  Preface," Cytogenet Genome Res 139 (3), 141-143 (2013)

H. H. Heng, G. Liu, J. B. Stevens, B. Y. Abdallah, S. D. Horne, K. J. Ye, S. W. Bremer, S. K. Chowdury and C. J. Ye.  "Karyotype heterogeneity and unclassified chromosomal abnormalities," Cytogenet Genome Res (3), 144-157 (2013)

J. B. Stevens, B. Y. Abdallah, G. Liu, S. D. Horne, S. W. Bremer, K. J. Ye, J. Y. Huang, M. Kurkinen, C. J. Ye and H. H. Heng.  "Heterogeneity of cell death," Cytogenet Genome Res 139 (3), 164-173 (2013)

S. D. Horne, B. Y. Abdallah, J. B. Stevens, G. Liu, K. J. Ye, S. W. Bremer and H. H. Heng.  "Genome constraint through sexual reproduction: application of 4D-Genomics in reproductive biology," Syst Biol Reprod Med 59 (3), 124-130 (2013)

S. D. Horne, J. B. Stevens, B. Y. Abdallah, G. Liu, S. W. Bremer, C. J. Ye and H. H. Heng.  "Why imatinib remains an exception of cancer research," J Cell Physiol 228 (4), 665-670 (2013)

J. S. Lee, R. Mendez, H. H. Heng, Z. Q. Yang and K. Zhang.  "Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation," Am J Transl Res 4 (1), 102-113 (2012)

H. H. Heng. "Biocomplexity: challenging reductionism," In: Handbook on Systems and Complexity in Health. Springer, In press (2012).

J. B. Stevens, B. Y. Abdallah, S. D. Horne, G. Liu, S. W. Bremer, and H. H. Heng. "Genetic and epigenetic heterogeneity in cancer," eLS (2011).

H. H. Heng, J. B. Stevens, S. W. Bremer, G. Liu, B. Y. Abdallah, and C. J. Ye. "Evolutionary mechanisms and diversity in cancer," Adv Cancer Res 112, 217-253 (2011).

J. B. Stevens, B. Y. Abdallah, G. Liu, C. J. Ye, S. D. Horne, G. Wang, S. Savasan, M. Shekhar, S. A. Krawetz, M. Huttemann, M. A. Tainsky, G. S. Wu, Y. Xie, K. Zhang, and H. H. Heng, "Diverse system stresses: common mechanisms of chromosome fragmentation," Cell Death Dis 2, e178 (2011).

H. H. Heng, G. Liu, J. B. Stevens, S. W. Bremer, K. J. Ye, B. Y. Abdallah, S. D. Horne, and C. J. Ye, "Decoding the genome beyond sequencing: The new phase of genomic research," Genomics (2011).

S. Chandrakasan, C. J. Ye, M. Chitlur, A. N. Mohamed, R. Rabah, A. Konski, H. H. Heng, and S. Savasan, "Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability," Pediatr Blood Cancer 56 (7), 1143-1145 (2011).

G. D. Johnson, A. E. Platts, C. Lalancette, R. Goodrich, H.H. Heng, and S. A. Krawetz, "Interrogating the transgenic genome: development of an interspecies tiling array," Syst Biol Reprod Med 57 (1-2), 54-62 (2011).

R. Gorelick and H. H. Heng, "Sex reduces genetic variation: a multidisciplinary review," Evolution 65 (4), 1088-1098 (2011).

J. B. Stevens, B. Y. Abdallah, S. M. Regan, G. Liu, S. W. Bremer, C. J. Ye, and H. H. Heng, "Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation," Mol Cytogenet 3, 20 (2010).

H. H. Heng, "Missing heritability and stochastic genome alterations," Nat Rev Genet 11 (11), 813 (2010).

H. H. Heng, G. Liu, J. B. Stevens, S. W. Bremer, K. J. Ye, and C. J. Ye, "Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy," Curr Drug Targets 11 (10), 1304-1316 (2010).

K. J. Drennan, A. K. Linnemann, A. E. Platts, H. H. Heng, D. R. Armant, and S. A. Krawetz, "Nuclear matrix association: switching to the invasive cytotrophoblast," Placenta 31 (5), 365-372 (2010).

HH Heng, J. B. Stevens, S. W. Bremer, K. J. Ye, G. Liu, and C. J. Ye, "The evolutionary mechanism of cancer," J Cell Biochem 109 (6), 1072-1084 (2010).

Heng HH. (2009). The genome-centric concept: resynthesis of evolutionary theory. BioEssays. 31: 512-25.

Heng HH, Bremer, S, Stevens, J, Ye, K, Liu, G and Ye CJ. (2009). Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective. Journal of Cellualr Physiology. 220: 538-547.

Ye CJ, Stevens JB, Liu G, Bremer SW, Jaiswal AS, Ye KJ, Lin MF, Lawrenson L, Lancaster WD, Kurkinen M, Liao JD, Gairola CG, Shekhar MP, Narayan S, Miller FR, Heng HH. (2009). Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer. J Cell Physiol. 219:288-300.

Ye CJ , Lawrenson L, Liu G, Stevens JB, Ye KJ, Bremer SW, and Heng HH, (2009). Chapter 19: Simultaneous fluorescence immunostaining and FISH. In Liehr T edited: Fluorescence in situ hybridization (FISH) – Application. Springer Publisher. Pp193-216.

Espino PS, Pritchard S, Heng HH, Davie JR. (2009). Induction of H3 phosphorylation at Serine 10 by the Ras-MARK pathway correlates with nonclonal chromosomal aberrations in pancreatic cancer cells. Int J Cancer 124(3):562-7.

Heng HH . (2008). The conflict between complex systems and reductionism. JAMA. 300: 1580-1581.

Whittington PJ, Piechocki MP, Heng HH, Jacob JB, Jones RF, Back JB and Wei WZ. (2008). DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies. Cancer Res. 68: 7502-7511.

Heng HH, Stevens J, Lawrenson L, Liu G, Ye KJ, Bremer, S and Ye, CJ. (2008). Patterns of genome dynamics and cancer evolution. Cellular Oncology 30:513-4.

Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M, Mackenzie RG. (2008). Stat3 is required in hypothalamic Agrp/Npy neurons for normal energy homeostasis. Endocrinology. 149:3346-54

Heng HH (2008). The gene-centric concept: a new liability? BioEssays 30: 196-187.

Heng HH (2007). Challenging reproduction assumptions. SCIENTIST 21: 16-16.

Heng HH (2007). Elimination of altered karyotypes by sexual reproduction preserves species identity. Genome 50: 517-524.

Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR.(2007). Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts. Int J Cancer. 120: 2127-2134.

Heng HH (2007). Cancer genome sequencing: the challenges ahead. BioEssays 29: 783-794.

Stevens JB, Liu G, Bremer SW, Ye KJ, Xu W, Sun Y, Wu GS, Savasan S, Krawetz SA, Ye CJ and Heng HH. (2007). Mitotic cell death by chromosome fragmentation. Cancer Research 67: 7686-7694.

Beatty, B., and Heng, HH. (2007). Gene mapping by Fluorescence in situ hybridization. In Meyer R ed Genomics and Genetics: From molecular details to analysis and techniques. Vol 2 p713-748. Wiley-VCH.

Ye CJ, Liu G, Bremer SW, Heng HH. (2007). Invited review: Cancer Genomics: The dynamics of cancer chromosomes and genomes. Cytogenetics and Genome Research: Cancer Genomics 118:237-246.

Heng HH , Stevens JB, Liu G, Bremer SW, Ye KJ, Reddy PV, Wu GS, Wang YA, Tainsky MA, Ye CJ. (2006) Stochastic cancer progression driven by non-clonal chromosome aberrations. Journal of Cellular Physiology 208: 461-472.

Heng HH , Bremer SW, Stevens J, Ye KJ, Miller F, Liu G, Ye CJ. (2006). Prospect: Cancer progression by non-clonal chromosome aberrations. J Cell Biochem. 98: 1424-1435 (featured by cover).

Heng HH ., Liu, G., Bremer, S. Ye, K.J., Stevens J., and Ye C.J. (2006). Clonal and non-cloal chromosome aberrations and genome variation and aberration. Genome 49: 195-204 (featured by cover).

Woodward KJ, Cundall M, Sperle K, Sistermans EA, Ross M, Howell G, Gribble SM, Burford DC, Carter NP, Hobson DL, Garbern JY, Kamholz J, Heng H , Hodes ME, Malcolm S, Hobson GM. (2005). Heterogeneous duplications in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and nonhomologous recombination. Am J Hum Genet . 77:966-87.

Roberts PC, Mottillo EP, Baxa AC, Heng HH , Doyon-Reale N, Gregoire L, Lancaster WD, Rabah R, Schmelz EM. (2005). Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model. Neoplasia 7:944-956.

Shen, K.C., Heng, H ., Wang, Y., Lu, S., Liu, G., Deng, C.H., Brooks , S.C. , and Wang, Y.A. (2005). ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development. Cancer research 65: 8747-8753.

Biliran H., Wang, Y., Banerjee, S., Xu, H, Heng, H., Thakur, A., Bolling, A., Sarkar, FH and Liao JD (2005). Overexpression of cyclin D1 promotors tumor cell growth and confers resistance to Cisplatin-mediated apoptosis in an elastase-myc transgene expression pancreatic tumor cell line. Clinical Cancer Research 11; 1075-6086 (cover and featured article).

Wu, XH., Avni, D., Li ,X., Zhao, Q., Lin,Y., Heng, H., and Livingston, D. (2004). SV40 T antigen interacts with Nbs1 to disrupt cellular replication control. Genes & Development 18: 1305-1316.

Derjuga A, Gourley TS, Holm TM, Heng HH , Shivdasani RA, Ahmed R, Andrews NC, Blank V . (2004). Complexity of CNC Transcription Factors as Revealed by Gene Targeting of the Nrf3 Locus. MCB 24: 3286-3294.

Heng, H H ., Goetze, S., Ye, C.J., Liu, G., Stevens, J.B., Bremer, S.W., Bode, J., Wykes, SM., and Krawetz, SA. (2004). Chromatin loops are selectively anchored using Scaffold/matrix attachment regions. J Cell Sci . 117: 999-1008 (featured article).

Heng, H.H.Q ., Stevens, J., Liu, G., Bremer, S.B. and Ye C.J. (2004). Imaging genome abnormalities in cancer research (invited review). Cell & Chromosomes 3:1

Beatty, B., and Heng, H.H. (2004). Gene mapping by Fluorescence in situ hybridization. In Meyer R ed Encyclopedia of Molecular Cell Biology and Molecular Medicine. Vol 5 p137-171. Wiley-VCH

Kolas, N.K., Yuan, L., Hoog, C., Heng, H.H.Q., Marcon, E.,, and Moens, P.B. (2003). Meiotic chromosome cores deficient in structural proteins SCP3 and SCP2 are capable of chromatin loop attachment with possible impaired specificity. Cytogent Genome Res (in press).

Heng, H.H.Q., Ye, C.J., Yang, FT., Ebrahim, S., Liu, G., Bremer, S., Thomas, MC., Ye. J., Chen, T.J., Tuck-Muller, C., Yu, J.W., Krawetz, SA., and Johnson, A (2003). Analysis of marker or complex chromosomal rearrangements present in pre-and postnatal karyotypes utilizing a combination of G-banding, SKY and FISH. Clinical Genetics 63: 358-367.

Bode, J., Goetze, S., Heng, HH., Krawetz, SA, and Benham, C. (2003). From DNA structure to gene expression: Mediators of nuclear compartmentalization and dynamics. Chromosome Res 11: 435-445.

Scherer, S et al, (2003). Human Chromosome 7: DNA Sequence and Biology. Science 300: 767-772.

Yang, LV., Heng, H.H., Wan, J.,, Southwood,C.M., Gow, A and Li, L. (2003) Alternate promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoisis and spermatogenesis. Developmental Dynamics. 228: 606-616.

Takeuchi, T., Heng, H.H.Q., Ye, C. J., Liang, S.B., Sonobe, H and Yuji Ohtsuki, Y. (2003). Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. Am J Pathology 163: 1395-1404.

Cheung, J., Wilson, MD., Zhang, J., Khaja R., MacDonal, JR., Heng, H.H.Q., Koop, B.F., and Scherer, SW. (2003). Recent segmental and gene duplications in the mouse genome. Genome Biology 4: R47.

Heng, H.H.Q (2002). High resolution FISH mapping using chromatin and DNA fiber. In: Beatty et al ed, FISH: A Practical Approach. p.77-92. Oxford University Press.

Shekhar, M.P.V., Lyakhovich, A., Visscher, D. W., Heng, H., and Kondrat, N. (2002). Rad 6 overexpression induces multinucleation, centrosome amplification, abnormal mitotic, aneuploidy, and transformation. Cancer Research 62: 2115-2124.

Dong, S., Leung, KKH., Pelling, A.L., Lee, PYT., Tang, A., Heng, HHQ., Tsui, L-C., Tease, C., Fisher, G., Stell, K.P., and Cheah, KSE (2002). Circling, deafness and yellow coat colour displayed by the chromosome 3 mouse mutant yellow submarine (Ysb) and light coat circling (Lcc). Genomics 79(6):777-84.

Schmid, C., Heng, H.H.Q., Rubin, C., Ye, C.J., and Krawetz, SA (2001). Sperm nuclear matrix of the PRM1-PRM2-TNP2 domain is independent of ALU methylation. Hum Mole Reproduction 7: 903-911.

Heng, H.H.Q., Krawetz, SK., Lu, W., Bremer, S., Liu, G., and Ye, C.J. (2001). Re-defining the chromatin loop domain. Cytogent Cell Genet 93: 155-161.

Ye, J., Lu, W., Moens, P., Liu, G., Bremer, S., Wang Y, Hughes, M., Krawetz, S., and Heng, H.H.Q. (2001). The combination of SKY and specific loci detection with FISH or Immunostaining. Cytogenetics and Cell Genetics 93: 195-202.

Heng, H.H.Q., Liu, G., Lu, W., Bremer, S., Ye C.J., Hughes, M., and Moens, P. (2001). Multicolor SKY painting of mouse meiotic chromosomes. Genome 44: 293-298.

Ding, B.C., Witt, T.L., Hukku, B., Heng, H., Zhang, L., and Matherly, L.H. (2001). Deletions and translocations of the reduced folate carrier gene are associate with profound loss of gene expression in methotrexate resistant K562 human erythroleukemia cells. Biochem. Pharmacol 61: 665-675.

Liu, G., Lu, W., Bremer, S., Hameister, H., Schreiner, B., Hughes, M., and Heng, H.H.Q. (2000). Spectral Karyotyping of Mouse Cell Line WMP2. Cytogenet Cell Genet 90: 271-274.

Lee DK, Lynch KR, Nguyen T, Im D, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng H.H.Q, Seeman P, George SR, O'Dowd BF, Marchese A. (2000). Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta 1490(3):311-323.

Heng, H.H.Q, Spyropoulos, B., Moens, PB (2000). DNA-protein in situ co-detection. Methods in Molecular Biology: In situ hybridization protocols. Vol: 123: 15-27. Clifton, New Jersey, Humana Press.

Heng, H.H.Q (2000). Released chromatin or DNA fiber preparation for high-resolution fiber FISH. Methods in Molecular Biology: In situ hybridization protocols. Vol: 123: 69-81. Clifton, New Jersey, Humana Press.

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