Find Dr. Henry Heng's research on PubMed and Scopus.


Browse our publications by year:

2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 20032002 | 2001 | 2000   


2015


Horne SD, Wexler M, Stevens JB, Heng HH. (2015). Insights on processes of evolutionary tumor growth. Atlas Genet Oncol Haematol, March 2015.  AtlasGeneticsOncology


Horne SD, Ye CJ, Abdallah BY, Liu G, Heng HH. (2015). Cancer genome evolution. Transl Cancer Res, 4.3: 303-313.  TheTCR


Horne SD, Pollick SA, Heng HH. (2015). Evolutionary mechanism unifies the hallmarks of cancer. Int J Cancer, 136.9: 2012-2021.  PubMed


2014

Horne SD, Heng HH. (2014). Genome chaos, chromothripsis and cancer evolution. J Cancer Stud Ther, 1.1: 1-6.  ScienceScript

Horne SD, Chowdhury SK, Heng HH. (2014). Stress, genomic adaptation, and the evolutionary trade-off. Front Genet, 5.92: 1-6. 
PubMed

Liu G, Stevens JB, Horne SD, Abdallah BY, Ye KJ, Bremer SW, Ye CJ, Chen DJ, Heng HH. (2014). Genome chaos: Survival strategy during crisis. Cell Cycle, 13.4: 528-537.  PubMed


Stevens JB, Liu G, Abdallah BY, Horne SD, Ye KJ, Bremer SW, Ye CJ, Krawetz SA, Heng HH. (2014). Unstable genomes elevate transcriptome dynamics. Int J Cancer, 134.9: 2074-2087.  PubMed


Heng HH. (2014). Distinguishing constitutional and acquired nonclonal aneuploidy. Proc Natl Acad Sci U S A, 111.11: E972.  PubMed

Abdallah BY, Horne SD, Kurkinen M, Stevens JB, Liu G, Ye CJ, Barbat J, Bremer SW, Heng HH. (2014). Ovarian cancer evolution through stochastic genome alterations: defining the genomic role in ovarian cancer. Syst Biol Reprod Med, 60.1: 2-13.  PubMed

2013

Abdallah BY, Horne SD, Stevens JB, Liu G, Ying AY, Vanderhyden B, Krawetz SA, Gorelick R, Heng HH. (2013). Single cell heterogeneity: Why unstable genomes are incompatible with average profiles. Cell Cycle, 12.23: 3640-3649.  PubMed

Heng HH. (2013). Genomics: HeLa genome versus donor's genome. Nature, 501.7466: 167.  PubMed

Heng HH, Bremer SW, Stevens JB, Horne SD, Liu G, Abdallah BY, Ye KJ, Ye CJ. (2013). Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution. Cancer Metastasis Rev, 32.3-4: 325-340.  PubMed

Heng HH. (2013). Special issue: Genome instability and cancer. Preface. Cancer Metastasis Rev, 32.3-4: 323-324.  PubMed

Stevens JB, Horne SD, Abdallah BY, Ye CJ, Heng HH. (2013). Chromosomal instability and transcriptome dynamics in cancer. Cancer Metastasis Rev, 32.3-4: 391-402.  PubMed

Heng HH. (2013). The contribution of genomic heterogeneity. Preface. Cytogenet Genome Res, 139.3: 141-143.  PubMed

Heng HH, Liu G, Stevens JB, Abdallah BY, Horne SD, Ye KJ, Bremer SW, Chowdhury SK, Ye CJ. (2013). Karyotype heterogeneity and unclassified chromosomal abnormalities. Cytogenet Genome Res, 139.3: 144-157.  PubMed

Stevens JB, Abdallah BY, Liu G, Horne SD, Bremer SW, Ye KJ, Huang JY, Kurkinen M, Ye CJ, Heng HH. (2013). Heterogeneity of cell death. Cytogenet Genome Res, 139.3: 164-173.  PubMed

Horne SD, Abdallah BY, Stevens JB, Liu G, Ye KJ, Bremer SW, Heng HH. (2013). Genome constraint through sexual reproduction: application of 4D-Genomics in reproductive biology. Syst Biol Reprod Med, 59.3: 124-130.  PubMed

Horne SD, Stevens JB, Abdallah BY, Liu G, Bremer SW, Ye CJ, Heng HH. (2013). Why imatinib remains an exception of cancer research. J Cell Physiol, 228.4: 665-670.  PubMed


Heng HH. (2013). Chapter 12: Bio-complexity: challenging reductionism. In: Handbook on Systems and Complexity in Health, eds. Sturmberg JP, Martin CM. (Springer), pp. 193-208.  Springer

2012


Lee JS, Mendez R, Heng HH, Yang ZQ, Zhang K. (2012). Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. Am J Transl Res, 4.1: 102-113.  PubMed


2011


Stevens JB, Abdallah BY, Horne SD, Liu G, Bremer SW, Heng HH. (2011). Genetic and epigenetic heterogeneity in cancer. eLS.  Wiley Online Library 


Heng HH, Stevens JB, Bremer SW, Liu G, Abdallah BY, Ye CJ. (2011). Evolutionary mechanisms and diversity in cancer. Adv Cancer Res, 112: 217-253.  PubMed

Stevens JB, Abdallah BY, Liu G, Ye CJ, Horne SD, Wang G, Savasan S, Shekhar M, Krawetz SA, Huttemann M, Tainsky MA, Wu GS, Xie Y, Zhang K, Heng HH. (2011). Diverse system stresses: common mechanisms of chromosome fragmentation. Cell Death Dis, 2: e178.  PubMed

Heng HH, Liu G, Stevens JB, Bremer SW, Ye KJ, Abdallah BY, Horne SD, Ye CJ. (2011). Decoding the genome beyond sequencing: The new phase of genomic research. Genomics, 98.4: 242-252.  
PubMed

Chandrakasan S, Ye CJ, Chitlur M, Mohamed AN, Rabah R, Konski A, Heng HH, Savasan S. (2011). Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. Pediatr Blood Cancer, 56.7: 1143-1145. 
PubMed

Johnson GD, Platts AE, Lalancette C, Goodrich R, Heng HH, Krawetz SA. (2011). Interrogating the transgenic genome: development of an interspecies tiling array. Syst Biol Reprod Med, 57.1-2: 54-62. 
PubMed

Gorelick R, Heng HH. (2011). Sex reduces genetic variation: a multidisciplinary review. Evolution, 65.4: 1088-1098.  
PubMed

2010


Stevens JB, Abdallah BY, Regan SM, Liu G, Bremer SW, Ye CJ, Heng HH. (2010). Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation. Mol Cytogenet, 3: 20.  
PubMed

Heng HH. (2010). Missing heritability and stochastic genome alterations. Nat Rev Genet, 11.11: 813.  
PubMed

Heng HH, Liu G, Stevens JB, Bremer SW, Ye KJ, Ye CJ. (2010). Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy. Curr Drug Targets, 11.10: 1304-1316.  
PubMed

Drennan KJ, Linnemann AK, Platts AE, Heng HH, Armant DR, Krawetz SA. (2010). Nuclear matrix association: switching to the invasive cytotrophoblast. Placenta, 31.5: 365-372. 
PubMed

Heng HH, Stevens JB, Bremer SW, Ye KJ, Liu G, Ye CJ. (2010). The evolutionary mechanism of cancer. J Cell Biochem, 109.6: 1072-1084.
PubMed

2009


Heng HH, Bremer SW, Stevens JB, Ye KJ, Liu G, Ye CJ. (2009). Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective. J Cell Physiol, 220.3: 538-547.  
PubMed

Heng HH. (2009). The genome-centric concept: resynthesis of evolutionary theory. Bioessays, 31.5: 512-525.  
PubMed

Ye CJ, Stevens JB, Liu G, Bremer SW, Jaiswal AS, Ye KJ, Lin MF, Lawrenson L, Lancaster WD, Kurkinen M, Liao JD, Gairola CG, Shekhar MP, Narayan S, Miller FR, Heng HH. (2009). Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer. J Cell Physiol, 219.2: 288-300.  
PubMed

Ye CJ, Lawrenson L, Liu G, Stevens JB, Ye KJ, Bremer SW, Heng HH. (2009). Chapter 19: Simultaneous fluorescence immunostaining and FISH. In: Fluorescence in situ hybridization (FISH) - Application, ed. Liehr T. (Springer Publishing), pp. 193-216.


Espino PS, Pritchard S, Heng HH, Davie JR. (2009). Genomic instability and histone H3 phosphorylation induction by the Ras-mitogen activated protein kinase pathway in pancreatic cancer cells. Int J Cancer, 124.3: 562-567. 
PubMed

2008

Heng HH, Stevens JB, Lawrenson L, Liu G, Ye KJ, Bremer SW, Ye CJ. (2008). Patterns of genome dynamics and cancer evolution. Cell Oncol, 30.6: 513-514.  
PubMed

Heng HH. (2008). The conflict between complex systems and reductionism. JAMA, 300.13: 1580-1581.  
PubMed

Whittington PJ, Piechocki MP, Heng HH, Jacob JB, Jones RF, Back JB, Wei WZ. (2008). DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies. Cancer Res, 68.18: 7502-7511. 
PubMed

Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M, Mackensie RG. (2008). Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y nerons for normal energy homeostasis. Endocrinology, 149.7: 3346-3354. 
PubMed

Heng HH. (2008). The gene-centric concept: a new liability? Bioessays, 30.2: 196-197. 
PubMed

2007


Heng HH. (2007). Challenging reproduction assumptions. Scientist, 21.12: 16.


Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR. (2007). Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts. Int J Cancer, 120.10: 2127-2134. 
PubMed

Ye CJ, Liu G, Bremer SW, Heng HH. (2007). The dynamics of cancer chromosomes and genomes. Cytogenet Genome Res, 118.2-4: 237-246. 
PubMed

Stevens JB, Liu G, Bremer SW, Ye KJ, Xu W, Xu J, Sun Y, Wu GS, Savasan S, Krawetz SA, Ye CJ, Heng HH. (2007). Mitotic cell death by chromosome fragmentation. Cancer Res, 67.16: 7686-7694. 
PubMed

Heng HH. (2007). Cancer genome sequencing: the challenges ahead. Bioessays, 29.8: 783-794. 
PubMed

Beatty B, Heng HH. (2007). Gene mapping by Fluorescence in situ hybridization. In: Genomics and Genetics: From molecular details to analysis and techniques, Vol 2, ed. Meyer R. (Wiley-VCH), pp. 713-748.


Heng HH. (2007). Elimination of altered karyotypes by sexual reproduction preserves species identity. Genome, 50.5: 517-524.  
PubMed

2006

Ye CJ, Stevens JB, Liu G, Ye KJ, Yang F, Bremer SW, Heng HH. (2006). Combined multicolor-FISH and immunostaining. Cytogenet Genome Res, 114.3-4: 227-234.
  PubMed

Heng HH, Stevens JB, Liu G, Bremer SW, Ye KJ, Reddy PV, Wu GS, Wang YA, Tainsky MA, Ye CJ. (2006). Stochastic cancer progression driven by non-clonal chromosome aberrations. J Cell Physiol, 208.2: 461-472. 
PubMed

Heng HH, Bremer SW, Stevens J, Ye KJ, Miller F, Liu G, Ye CJ. (2006). Cancer progression by non-clonal chromosome aberrations. J Cell Biochem, 98.6: 1424-1435. 
PubMed

Heng HH, Liu G, Bremer S, Ye KJ, Stevens J, Ye CJ. (2006). Clonal and non-clonal chromosome aberrations and genome variation and aberration. Genome, 49.3: 195-204. (Featured by cover). 
PubMed

DiPierdomenico J, Ying H, Lin F, Heng HH. (2006). A mathematical model relating chromosome aberrations to cancer progression. Conf Proc IEEE Eng Med Biol Soc, 1: 2028-2031. 
PubMed

2005

Woodward KJ, Cundall M, Sperie K, Sistermans EA, Ross M, Howell G, Gribble SM, Burford DC, Carter NP, Hobson DL, Garbern JY, Kamholz J, Heng H, Hodes ME, Malcolm S, Hobson GM. (2005). Heterogeneous duplication in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and nonhomologous recombination. Am J Hum Genet, 77.6: 966-987. 
PubMed

Roberts PC, Mottillo EP, Baxa AC, Heng HH, Doyon-Reale N, Gregoire L, Lancaster WD, Rabah R, Schmelz EM. (2005). Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model. Neoplasia, 7.10: 944-956. 
PubMed

Shen KC, Heng H, Wang Y, Lu S, Liu G, Deng CH, Brooks SC, Wang YA. (2005). ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development. Cancer Res, 65.19: 8747-8753. 
PubMed

Biliran H, Wang Y, Banerjee S, Xu H, Heng H, Thakur A, Bolling A, Sarkar FH, Liao JD. (2005). Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene expression pancreatic tumor cell line. Clin Cancer Res, 11.16: 6075-6086. (Cover and featured article). 
PubMed

Heng HH, Windle B, Tsui LC. (2005). High-resolution FISH analysis. Curr Protoc Hum Genet Chapter 4, Unit 4 5. 
PubMed

2004

Wu XH, Avni D, Li X, Zhao Q, Lin Y, Heng H, Livingston D. (2004). SV40 T antigen interacts with Nbs1 to disrupt cellular replication control. Genes Dev, 18.11: 1305-1316. 
PubMed

Derjuga A, Gourley TS, Holm TM, Heng HH, Shivdasani RA, Ahmed R, Andrews NC, Blank V. (2004). Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol, 24.8: 3286-3294. 
PubMed

Heng HH, Goetze S, Ye CJ, Liu G, Stevens JB, Bremer SW, Wykes SM, Bode J, Krawetz SA. (2004). Chromatin loops are selectively anchored using scaffold/matrix-attachment regions. J Cell Sci, 117.Pt7: 999-1008 (Featured article). 
PubMed

Heng HH, Stevens JB, Liu G, Bremer SW, Ye CJ. (2004). Imaging genome abnormalities in cancer research. Cell Chromosome, 3.1: 1 (Invited review).  
PubMed

Beatty B, Heng HH. (2004). Gene mapping by Fluorescence in situ hybridization. In: Encyclopedia of molecular cell biology and molecular medicine, Vol 5, ed. Meyer R. (Wiley-VCH), pp. 137-171.


Kolas NK, Yuan L, Hoog C, Heng HHQ, Marcon E, Moens PB. (2004). Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment. Cytogenet Genome Res, 105.2-4: 182-188. 
PubMed

2003

Heng HH, Ye CJ, Yang F, Ebrahim S, Liu G, Bremer SW, Thomas CM, Ye J, Chen TJ, Tuck-Miller C, Yu JW, Krawetz SA, Johnson A. (2003). Analysis of marker or complex chromosomal rearrangements present in pre- and post-natal karyotypes utilizing a combination of G-banding, spectral karyotyping and fluorescence in situ hybridization. Clin Genet, 63.5: 358-367. 
PubMed

Bode J, Goetze S, Heng HH, Krawetz SA, Benham C. (2003). From DNA structure to gene expression: Mediators of nuclear compartmentalization and dynamics. Chromosome Res, 11.5: 435-445. 
PubMed

Scherer S, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Guesella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ,
Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC. (2003). Human chromosome 7: DNA sequence and biology. Science, 300.5620: 767-772.  PubMed

Yang LV, Heng HH, Wan J, Southwood CM, Gow A, Li L. (2003). Alternate promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiese and spermatogenesis. Dev Dyn, 228.4: 606-616. 
PubMed

Takeuchi T, Heng HHQ, Ye CJ, Liang SB, Sonobe H, Yuji Ohtsuki Y. (2003). Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. Am J Pathol, 163.4: 1395-1404. 
PubMed

Cheung J, Wilson MD, Zhang J, Khaja R, MacDonald JR, Heng HHQ, Koop BF, Scherer SW. (2003). Recent segmental and gene duplications in the mouse genome. Genome Biol, 4.8: R47. 
PubMed

2002

Heng HHQ. (2002). High resolution FISH mapping using chromatin and DNA fiber. In: FISH: A practical approach, eds. Beatty et al. (Oxford University Press), pp. 77-92.


Shekhar MPV, Lyakhovich A, Visscher DW, Heng H, Kondrat N. (2002). Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitotic, aneuploidy, and transformation. Cancer Res, 62.7: 2115-2124. 
PubMed

Dong S, Leung KKH, Pelling AL, Lee PYT, Tang A, Heng HHQ, Tsui LC, Tease C, Fisher G, Stell KP, Cheah KSE. (2002). Circling, deafness, and yellow coat colour displayed by the chromosome 3 mouse mutant yellow submarine (Ysb) and light coat circling (Lcc). Genomics, 79.6: 777-784. 
PubMed

2001


Schmid C, Heng HHQ, Rubin C, Ye CJ, Krawetz SA. (2001). Sperm nuclear matrix of the PRM1-->PRM2-->TNP2 domain is independent of Alu methylation. Mol Hum Reprod, 7.10: 903-911. 
PubMed

Heng HH, Liu G, Lu W, Bremer S, Ye CJ, Hughes M, Moens P. (2001). Spectral karyotyping (SKY) of mouse meiotic chromosomes. Genome, 44.2: 293-298. 
PubMed

Ye CJ, Lu W, Liu G, Bremer SW, Wang YA, Moens P, Hughes M, Krawetz SA, Heng HH. (2001). The combination of SKY and specific loci detection with FISH or immunostaining. Cytogenet Cell Genet, 93.3-4: 195-202. 
PubMed

Heng HH, Krawetz SA, Lu W, Bremer S, Liu G, Ye CJ. (2001). Re-defining the chromatin loop domain. Cytogenet Cell Genet, 93.3-4: 155-161. 
PubMed

Ding BC, Witt TL, Hukku B, Heng H, Zhang L, Matherly LH. (2001). Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. Biochem Pharamcol, 61.6: 665-675. 
PubMed

2000


Liu G, Lu W, Bremer S, Hameister H, Schreiner B, Hughes M, Heng HH. (2000). Spectral karyotyping of mouse cell line WMP2. Cytogenet Cell Genet, 90.3-4: 271-274.  
PubMed

Lee DK, Lynch KR, Nguyen T, Im D, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HHQ, Seeman P, George SR, O'Dowd BF, Marchese A. (2000). Cloning and characterization of additional members of the G protein-coupled family. Biochim Biophys Acta, 1490.3: 311-323. 
PubMed

Heng HH. (2000). Released chromatin or DNA fiber preparations for high-resolution fiber FISH. Methods Mol Biol, 123: 69-81. 
PubMed

Heng HH, Spyropoulos B, Moens PB. (2000). DNA-protein in situ covisualization for chromosome analysis. Methods Mol Biol, 123: 15-27. 
PubMed