Find Dr. Henry Heng's research on PubMed and Scopus.


Browse our publications by year:

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 20032002 | 2001 | 2000   


2014

G. Liu, J. B. Stevens, S. D. Horne, B. Y. Abdallah, K. J. Ye, S. W. Bremer, C. J. Ye, D. J. Chen, and H. H. Heng.  "Genome chaos: Survival strategy during crisis."  Cell Cycle 13 (4), 528-537 (2014).  PubMed

J. B. Stevens, G. Liu, B. Y. Abdallah, S. D. Horne, K. J. Ye, S. W. Bremer, C. J. Ye, S. A. Krawetz, and H. H. Heng.  "Unstable genomes elevate transcriptome dynamics."  Int J Cancer 134 (9), 2074-2087 (2014).  PubMed


H. H. Heng.  "Distinguishing constitutional and acquired nonclonal aneuploidy."  Proc Natl Acad Sci U S A 111 (11), E972 (2014).  PubMed

B. Y. Abdallah, S. D. Horne, M. Kurkinen, J. B. Stevens, G. Liu, C. J. Ye, J. Barbat, S. W. Bremer, and H. H. Heng.  "Ovarian cancer evolution through stochastic genome alterations: defining the genomic role in ovarian cancer."  Syst Biol Reprod Med 60 (1), 2-13 (2014).  PubMed

2013

B. Y. Abdallah, S. D. Horne, J. B. Stevens, G. Liu, A. Y. Ying, B. Vanderhyden, S. A. Krawetz, R. Gorelick, and H. H. Heng.  "Single cell heterogeneity: Why unstable genomes are incompatible with average profiles." Cell Cycle 12 (23), 3640-3649 (2013).  PubMed

H. H. Heng.  "Genomics: HeLa genome versus donor's genome."  Nature 501 (7466), 167 (2013).  PubMed

H. H. Heng, S. W. Bremer, J. B. Stevens, S. D. Horne, G. Liu, B. Y. Abdallah, K. J. Ye, and C. J. Ye.  "Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution." Cancer Metastasis Rev 32 (3-4), 325-340 (2013).  PubMed

H. H. Heng.  "Special issue: Genome instability and cancer. Preface." Cancer Metastasis Rev 32 (3-4), 323-324 (2013).  PubMed

J. B. Stevens, S. D. Horne, B. Y. Abdallah, C. J. Ye, and H. H. Heng.  "Chromosomal instability and transcriptome dynamics in cancer."  Cancer Metastasis Rev 32 (3-4), 391-402 (2013).  PubMed

H. H. Heng.  "The contribution of genomic heterogeneity.  Preface."  Cytogenet Genome Res 139 (3), 141-143 (2013).  PubMed

H. H. Heng, G. Liu, J. B. Stevens, B. Y. Abdallah, S. D. Horne, K. J. Ye, S. W. Bremer, S. K. Chowdury, and C. J. Ye.  "Karyotype heterogeneity and unclassified chromosomal abnormalities."  Cytogenet Genome Res 139 (3), 144-157 (2013).  PubMed

J. B. Stevens, B. Y. Abdallah, G. Liu, S. D. Horne, S. W. Bremer, K. J. Ye, J. Y. Huang, M. Kurkinen, C. J. Ye, and H. H. Heng.  "Heterogeneity of cell death."  Cytogenet Genome Res 139 (3), 164-173 (2013).  PubMed

S. D. Horne, B. Y. Abdallah, J. B. Stevens, G. Liu, K. J. Ye, S. W. Bremer, and H. H. Heng.  "Genome constraint through sexual reproduction: application of 4D-Genomics in reproductive biology." Syst Biol Reprod Med 59 (3), 124-130 (2013).  PubMed

S. D. Horne, J. B. Stevens, B. Y. Abdallah, G. Liu, S. W. Bremer, C. J. Ye, and H. H. Heng.  "Why imatinib remains an exception of cancer research."  J Cell Physiol 228 (4), 665-670 (2013).  PubMed


H. H. Heng.  "Chapter 12: Bio-complexity: challenging reductionism." In: Handbook on Systems and Complexity in Health, 193-208.  J. P. Sturmberg and C. M. Martin (Eds). Springer (2013).  Springer

2012


J. S. Lee, R. Mendez, H. H. Heng, Z. Q. Yang, and K. Zhang.  "Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation," Am J Transl Res 4 (1), 102-113 (2012).  PubMed


2011


J. B. Stevens, B. Y. Abdallah, S. D. Horne, G. Liu, S. W. Bremer, and H. H. Heng.  "Genetic and epigenetic heterogeneity in cancer," eLS (2011). Wiley Online Library 


H. H. Heng, J. B. Stevens, S. W. Bremer, G. Liu, B. Y. Abdallah, and C. J. Ye.  "Evolutionary mechanisms and diversity in cancer," Adv Cancer Res 112, 217-253 (2011). PubMed

J. B. Stevens, B. Y. Abdallah, G. Liu, C. J. Ye, S. D. Horne, G. Wang, S. Savasan, M. Shekhar, S. A. Krawetz, M. Huttemann, M. A. Tainsky, G. S. Wu, Y. Xie, K. Zhang, and H. H. Heng, "Diverse system stresses: common mechanisms of chromosome fragmentation," Cell Death Dis 2, e178 (2011). PubMed

H. H. Heng, G. Liu, J. B. Stevens, S. W. Bremer, K. J. Ye, B. Y. Abdallah, S. D. Horne, and C. J. Ye, "Decoding the genome beyond sequencing: The new phase of genomic research," Genomics 98 (4), 242-252 (2011).
PubMed

S. Chandrakasan, C. J. Ye, M. Chitlur, A. N. Mohamed, R. Rabah, A. Konski, H. H. Heng, and S. Savasan, "Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability," Pediatr Blood Cancer 56 (7), 1143-1145 (2011). 
PubMed

G. D. Johnson, A. E. Platts, C. Lalancette, R. Goodrich, H.H. Heng, and S. A. Krawetz, "Interrogating the transgenic genome: development of an interspecies tiling array," Syst Biol Reprod Med 57 (1-2), 54-62 (2011). 
PubMed

R. Gorelick and H. H. Heng, "Sex reduces genetic variation: a multidisciplinary review," Evolution 65 (4), 1088-1098 (2011).
PubMed

2010


J. B. Stevens, B. Y. Abdallah, S. M. Regan, G. Liu, S. W. Bremer, C. J. Ye, and H. H. Heng, "Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation," Mol Cytogenet 3, 20 (2010).
PubMed

H. H. Heng, "Missing heritability and stochastic genome alterations," Nat Rev Genet 11 (11), 813 (2010).
PubMed

H. H. Heng, G. Liu, J. B. Stevens, S. W. Bremer, K. J. Ye, and C. J. Ye, "Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy," Curr Drug Targets 11 (10), 1304-1316 (2010).
PubMed

K. J. Drennan, A. K. Linnemann, A. E. Platts, H. H. Heng, D. R. Armant, and S. A. Krawetz, "Nuclear matrix association: switching to the invasive cytotrophoblast," Placenta 31 (5), 365-372 (2010). 
PubMed

H. H. Heng, J. B. Stevens, S. W. Bremer, K. J. Ye, G. Liu, and C. J. Ye, "The evolutionary mechanism of cancer," J Cell Biochem 109 (6), 1072-1084 (2010).
PubMed

2009


H. H. Heng, S. W. Bremer, J. B. Stevens, K. J. Ye, G. Liu, and C. J. Ye, "Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective," J Cell Physiol 220 (3), 538-547 (2009).
PubMed

H. H. Heng, "The genome-centric concept: resynthesis of evolutionary theory," Bioessays 31 (5), 512-525 (2009).
PubMed

C. J. Ye, J. B. Stevens, G. Liu, S. W. Bremer, A. S. Jaiswal, K. J. Ye, M. F. Lin, L. Lawrenson, W. D. Lancaster, M. Kurkinen, J. D. Liao, C. G. Gairola, M. P. Shekhar, S. Narayan, F. R. Miller, and H. H. Heng, "Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer," J Cell Physiol 219 (2), 288-300 (2009).
PubMed

C. J. Ye, L. Lawrenson, G. Liu, J. B. Stevens, K. J. Ye, S. W. Bremer, and H. H. Heng.  Chapter 19: Simultaneous fluorescence immunostaining and FISH.  In Liehr T edited: Fluorescence in situ hybridization (FISH) - Application.  Springer Publishing.  193-216 (2009).


P. S. Espino, S. Pritchard, H. H. Heng, and J. R. Davie.  "Genomic instability and histone H3 phosphorylation induction by the Ras-mitogen activated protein kinase pathway in pancreatic cancer cells," Int J Cancer 124 (3), 562-567 (2009). 
PubMed

2008

H. H. Heng, J. B. Stevens, L. Lawrenson, G. Liu, K. J. Ye, S. W. Bremer, and C. J. Ye, "Patterns of genome dynamics and cancer evolution," Cell Oncol 30 (6), 513-514 (2008).
PubMed

H. H. Heng, "The conflict between complex systems and reductionism," JAMA 300 (13), 1580-1581 (2008).
PubMed

P. J. Whittington, M. P. Piechocki, H. H. Heng, J. B. Jacob, R. F. Jones, J. B. Back, and W. Z. Wei, "DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies," Cancer Res 68 (18), 7502-7511 (2008). 
PubMed

L. Gong, F. Yao, K. Hockman, H. H. Heng, G. J. Morton, K. Takeda, S. Akira, M. J. Low, M. Rubinstein, R. G. Mackensie, "Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis," Endocrinology 149(7), 3346-3354 (2008). 
PubMed

H. H. Heng, "The gene-centric concept: a new liability?," Bioessays 30 (2), 196-197 (2008).
PubMed

2007


H. H. Heng, "Challenging reproduction assumptions," Scientist 21 (12), 16 (2007).


L. R. Tait, R. J. Pauley, S. J. Santner, G. H. Heppner, H. H. Heng, J. W. Rak, and F. R. Miller, "Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts," Int J Cancer 120 (10), 2127-2134 (2007). 
PubMed

C. J. Ye, G. Liu, S. W. Bremer, and H. H. Heng, "The dynamics of cancer chromosomes and genomes," Cytogenet Genome Res 118 (2-4), 237-246 (2007).
PubMed

J. B. Stevens, G. Liu, S. W. Bremer, K. J. Ye, W. Xu, J. Xu, Y. Sun, G. S. Wu, S. Savasan, S. A. Krawetz, C. J. Ye, and H. H. Heng, "Mitotic cell death by chromosome fragmentation," Cancer Res 67 (16), 7686-7694 (2007).
PubMed

H. H. Heng, "Cancer genome sequencing: the challenges ahead," Bioessays 29 (8), 783-794 (2007).
PubMed

B. Beatty and H. H. Heng, "Gene mapping by Fluorescence in situ hybridization," In Meyer R ed: Genomics and Genetics: From molecular details to analysis and techniques, Wiley-VCH, Vol 2, 713-748 (2007).


H. H. Heng, "Elimination of altered karyotypes by sexual reproduction preserves species identity," Genome 50 (5), 517-524 (2007).
PubMed

2006

C. J. Ye, J. B. Stevens, G. Liu, K. J. Ye, F. Yang, S. W. Bremer, and H. H. Heng, "Combined multicolor-FISH and immunostaining," Cytogenet Genome Res 114 (3-4), 227-234 (2006).
PubMed

H. H. Heng, J. B. Stevens, G. Liu, S. W. Bremer, K. J. Ye, P. V. Reddy, G. S. Wu, Y. A. Wang, M. A. Tainsky, and C. J. Ye, "Stochastic cancer progression driven by non-clonal chromosome aberrations," J Cell Physiol 208 (2), 461-472 (2006).
PubMed

H. H. Heng, S. W. Bremer, J. Stevens, K. J. Ye, F. Miller, G. Liu, and C. J. Ye, "Cancer progression by non-clonal chromosome aberrations," J Cell Biochem 98 (6), 1424-1435 (2006).
PubMed

H. H. Heng, G. Liu, S. Bremer, K. J. Ye, J. Stevens, and C. J. Ye, "Clonal and non-clonal chromosome aberrations and genome variation and aberration," Genome 49 (3), 195-204 (2006) (featured by cover).
PubMed

J. DiPierdomenico, H. Ying, F. Lin, and H. H. Heng, "A mathematical model relating chromosome aberrations to cancer progression," Conf Proc IEEE Eng Med Biol Soc 1, 2028-2031 (2006).
PubMed

2005

K. J. Woodward, M. Cundall, K. Sperle, E. A. Sistermans, M. Ross, G. Howell, S. M. Gribble, D. C. Burford, N. P. Carter, D. L. Hobson, J. Y. Garbern, J. Kamholz, H. Heng, M. E. Hodes, S. Malcolm, and G. M. Hobson, " Heterogeneous duplications in patients with Pelizaeus-Merzbacher disease suggest a mechanism of coupled homologous and nonhomologous recombination," Am J Hum Genet 77 (6), 966-987 (2005). 
PubMed

P. C. Roberts, E. P. Mottillo, A. C. Baxa, H. H. Heng, N. Doyon-Reale, L. Gregoire, W. D. Lancaster, R. Rabah, and E. M. Schmelz, "Sequential molecular and cellular events during neoplastic progression: a mouse syngeneic ovarian cancer model," Neoplasia 7 (10), 944-956 (2005). 
PubMed

K. C. Shen, H. Heng, Y. Wang, S. Lu, G. Liu, C. H. Deng, S. C. Brooks, and Y. A. Wang, "ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development," Cancer Res 65 (19), 8747-8753 (2005). 
PubMed

H. Biliran, Y. Wang, S. Banerjee, H. Xu, H. Heng, A. Thakur, A. Bolling, F. H. Sarkar, and J. D. Liao, "Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene expression pancreatic tumor cell line," Clin Cancer Res 11 (16), 6075-6086 (2005) (cover and featured article). 
PubMed

H. H. Heng, B. Windle, and L. C. Tsui, "High-resolution FISH analysis," Curr Protoc Hum Genet Chapter 4, Unit 4 5 (2005).
PubMed

2004

X. H. Wu, D. Avni, X. Li, Q. Zhao, Y. Lin, H. Heng, and D. Livingston, "SV40 T antigen interacts with Nbs1 to disrupt cellular replication control," Genes Dev 18 (11), 1305-1316 (2004). 
PubMed

A. Derjuga, T. S. Gourley, T. M. Holm, H. H. Heng, R. A. Shivdasani, R. Ahmed, N. C. Andrews, and V. Blank, "Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus," Mol Cell Biol 24 (8), 3286-3294 (2004). 
PubMed

H. H. Heng, S. Goetze, C. J. Ye, G. Liu, J. B. Stevens, S. W. Bremer, S. M. Wykes, J. Bode, and S. A. Krawetz, "Chromatin loops are selectively anchored using scaffold/matrix-attachment regions," J Cell Sci 117 (Pt 7), 999-1008 (2004) (featured article).
PubMed

H. H. Heng, J. B. Stevens, G. Liu, S. W. Bremer, and C. J. Ye, "Imaging genome abnormalities in cancer research," Cell Chromosome 3 (1), 1 (2004) (invited review).
PubMed

B. Beatty and H. H. Heng, Gene mapping by Fluorescence in situ hybridization, In R. Meyer ed: Encyclopedia of molecular cell biology and molecular medicine, Wiley-VCH, Vol 5, 137-171 (2004).


N. K. Kolas, L. Yuan, C. Hoog, H. H. Q. Heng, E. Marcon, and P. B. Moens, "Male mouse meiotic chromosome cores deficient in structual proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment," Cytogenet Genome Res 105 (2-4), 182-188 (2004). 
PubMed

2003

H. H. Heng, C. J. Ye, F. Yang, S. Ebrahim, G. Liu, S. W. Bremer, C. M. Thomas, J. Ye, T. J. Chen, C. Tuck-Muller, J. W. Yu, S. A. Krawetz, and A. Johnson, "Analysis of marker or complex chromosomal rearrangements present in pre- and post-natal karyotypes utilizing a combination of G-banding, spectral karyotyping and fluorescence in situ hybridization," Clin Genet 63 (5), 358-367 (2003).
PubMed

J. Bode, S. Goetze, H. H. Heng, S. A. Krawetz, and C. Benham, "From DNA structure to gene expression: Mediators of nuclear compartmentalization and dynamics," Chromosome Res 11 (5), 435-445 (2003). 
PubMed

S. Scherer, J. Cheung, J. R. MacDonald, L. R. Osborne, K. Nakabayashi, J. A. Herbrick, A. R. Carson, L. Parker-Katiraee, J. Skaug, R. Khaja, J. Zhang, A. K. Hudek, M. Li, M. Haddad, G. E. Duggan, B. A. Fernandez, E. Kanematsu, S. Gentles, C. C. Christopoulos, S. Choufani, D. Kwasnicka, X. H. Zheng, Z. Lai, D. Nusskern, Q. Zhang, Z. Gu, F. Lu, S. Zeesman, M. J. Nowaczyk, I. Teshima, D. Chitayat, C. Shuman, R. Weksberg, E. H. Zackai, T. A. Grebe, S. R. Cox, S. J. Kirkpatrick, N. Rahman, J. M. Friedman, H. H. Heng, P. G. Pelicci, F. Lo-Coco, E. Belloni, L. G. Shaffer, B. Pober, C. C. Morton, J. F. Gusella, G. A. Bruns, B. R. Korf, B. J. Quade, A. H. Ligon, H. Ferguson, A. W. Higgins, N. T. Leach, S. R. Herrick, E. Lemyre, C. G. Farra, H. G. Kim, A. M. Summers, K. W. Gripp, W. Roberts, P. Szatmari, E. J. Winsor, K. H. Grzeschik, A. Teebi, B.A. Minassian, J. Kere, L. Armengol, M. A. Pujana, X. Estivill, M. D. Wilson, B. F. Koop, S. Tosi, G. E. Moore, A. P. Boright, E. Zlotorynski, B. Kerem, P. M. Kroisel, E. Petek, D. G. Oscier, S. J. Mould, H. Döhner, K. Döhner, J. M. Rommens, J. B. Vincent, J. C. Venter, P. W. Li, R. J. Mural, M. D. Adams, L. C. Tsui, "Human chromosome 7: DNA sequence and biology," Science 300 (5620), 767-72 (2003). 
PubMed

L. V. Yang, H. H. Heng, J. Wan, C. M. Southwood, A. Gow, and L. Li, "Alternate promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis," Dev Dyn 228 (4), 606-616 (2003). 
PubMed

T. Takeuchi, H. H. Q. Heng, C. J. Ye, S. B. Liang, H. Sonobe, and Y. Yuji Ohtsuki, "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma," Am J Pathol 163 (4), 1395-1404 (2003). 
PubMed

J. Cheung, M. D. Wilson, J. Zhang, R. Khaja, J. R. MacDonald, H. H. Q. Heng, B. F. Koop, and S. W. Scherer, "Recent segmental and gene duplications in the mouse genome," Genome Biol 4 (8), R47 (2003). 
PubMed

2002

H. H. Q. Heng, "High resolution FISH mapping using chromatin and DNA fiber," In Beatty et al. ed: FISH: A practical approach, Oxford University Press, 77-92 (2002).


M. P. V. Shekhar, A. Lyakhovich, D. W. Visscher, H. Heng, and N. Kondrat, "Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitotic, aneuploidy, and transformation," Cancer Res 62 (7), 2115-2124 (2002). 
PubMed

S. Dong, K. K. H. Leung, A. L. Pelling, P. Y. T. Lee, A. Tang, H. H. Q. Heng, L-C. Tsui, C. Tease, G. Fisher, K. P. Stell, and K. S. E. Cheah, "Circling, deafness, and yellow coat colour displayed by the chromosome 3 mouse mutant yellow submarine (Ysb) and light coat circling (Lcc)," Genomics 79 (6), 777-784 (2002). 
PubMed

2001


C. Schmid, H. H. Q. Heng, C. Rubin, C. J. Ye, and S. A. Krawetz, "Sperm nuclear matrix of the PRM1-->PRM2-->TNP2 domain is independent of Alu methylation," Mol Hum Reprod 7 (10), 903-911 (2001). 
PubMed

H. H. Heng, G. Liu, W. Lu, S. Bremer, C. J. Ye, M. Hughes, and P. Moens, "Spectral karyotyping (SKY) of mouse meiotic chromosomes," Genome 44 (2), 293-298 (2001).
PubMed

C. J. Ye, W. Lu, G. Liu, S. W. Bremer, Y. A. Wang, P. Moens, M. Hughes, S. A. Krawetz, and H. H. Heng, "The combination of SKY and specific loci detection with FISH or immunostaining," Cytogenet Cell Genet 93 (3-4), 195-202 (2001).
PubMed

H. H. Heng, S. A. Krawetz, W. Lu, S. Bremer, G. Liu, and C. J. Ye, "Re-defining the chromatin loop domain," Cytogenet Cell Genet 93 (3-4), 155-161 (2001).
PubMed

B. C. Ding, T. L. Witt, B. Hukku, H. Heng, L. Zhang, and L. H. Matherly, "Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells," Biochem Pharmacol 61 (6), 665-675 (2001). 
PubMed

2000


G. Liu, W. Lu, S. Bremer, H. Hameister, B. Schreiner, M. Hughes, and H. H. Heng, "Spectral karyotyping of mouse cell line WMP2," Cytogenet Cell Genet 90 (3-4), 271-274 (2000).
PubMed

D. K. Lee, K. R. Lynch, T. Nguyen, D. Im, R. Cheng, V. R. Saldivia, Y. Liu, I. S. Liu, H. H. Q. Heng, P. Seeman, S. R. George, B. F. O'Dowd, and A. Marchese, "Cloning and characterization of additional members of the G protein-coupled family," Biochim Biophys Acta 1490 (3), 311-323 (2000). 
PubMed

H. H. Heng, "Released chromatin or DNA fiber preparations for high-resolution fiber FISH," Methods Mol Biol 123, 69-81 (2000).
PubMed

H. H. Heng, B. Spyropoulos, and P. B. Moens, "DNA-protein in situ covisualization for chromosome analysis," Methods Mol Biol 123, 15-27 (2000).
PubMed