|John Kamholz, M.D., Ph.D.
3101 Elliman Building
421 E. Canfield Avenue
Detroit, MI 48201
John Kamholz MD, PhD is currently a Professor of Neurology, a Professor in the Center for Molecular Medicine and Genetics, and a member of the Graduate Group in Genetics and Molecular Biology. He has served on the Fellowship Committee for the National MS Society, the Medical Advisory Committee of the Muscular Dystrophy Association, and is on the Scientific Advisory Committee for the Pelizaeus-Merzbacher Disease Foundation. He has been an associate editor for the Journal of Neuropathology and Experimental Neurology, and has reviewed papers for a number of peer-reviewed journals including the Annals of Neurology, Journal of Neuroscience, Journal of Neurological Science, Neurology, Journal of Neuroscience Research, Journal of Neurochemistry, Molecular and Cellular Neuroscience, and Biophysics Journal. He was previously a member of the Department of Neurology at the
Dr. Kamholz research and clinical interests are the regulation and structure of myelin and diseases of the myelin sheath, including multiple sclerosis (MS), a demyelinating disease of the central nervous system, and Charcot-Marie-Tooth disease (CMT), a dysmyelinating disease of the peripheral nervous system. His research include basic studies on the structure and function of the major myelin proteins, myelin protein zero (MPZ) and proteolipid protein (PLP); clinical studies on the phenotype and natural history of patients with inherited diseases of myelin; and clinical trials for the treatment of patient with MS. He is currently funded by the National Institute of Health, the National MS Society, and the Muscular Dystrophy Association.
Daffu, G, Sohi, J, and Kamholz, J. (2008). The presence of the 35 amino acid PLP-specific domain alters transmembrane helix (TMH) packing and leads to PLP dimerization at cysteine residues within TMH1: implications for the pathogenesis of Pelizaeus-Merzbacher disease. (Submitted).
Southwood, C, He, C, Garbern, J, Kamholz, J, Arroyo, E, and Gow, A. CNS myelin paranodes require Nkx6-2 homeodomain transcriptional activity for normal structure. J. Neurosci, 24: 11215-25, 2004.
Awards and Honors
Honorable Mention, S. Weir Mitchell Award, American Academy of Neurology, 1986
Member, Scientific Advisory Committee National MS Society, 1996-2001
Elected Member, American Neurological Association. 1996
Member, Medical Advisory Board, Muscular Dystrophy Association, 2002-2008
Listed in "Best Doctors in America", 1997, 1998; 2001-2008