|Monica Uddin, PhD
3309 Scott Hall
540 E. Canfield Ave.
Wayne State University School of Medicine
Detroit, MI 48201
Uddin Research Group
Work in the Uddin research group focusses on investigating the molecular underpinnings of commonly occurring mood-anxiety disorders, with a particular emphasis on post-traumatic stress disorder (PTSD). We seek to identify genetic, epigenetic, and other biologic signatures associated with risk for, and resilience to, mental illness using samples drawn principally from community-based settings. Major areas of research include: characterizing genomic phenotypes of mental illness; assessing gene-environment interactions in psychiatric disorders; and investigating developmental differences in the molecular contributions to mental illness. Ongoing projects use genetic and genomic data obtained from large, population-based datasets, in order to provide population-level estimates of molecular and environmental risk factors that can inform interventions to reduce the burden of mental illness.
Uddin M, Amstadter AB, Nugent NR, Koenen KC. (in press). Genetics and genomics of post-traumatic stress disorder. Handbook of Traumatic Stress Disorders, Oxford University Press.
Koenen KC, Uddin M, Chang SC, Aiello AE, Wildman DE, de los Santos R, Goldmann E, Galea S (2011). Methylation of SLC6A4 moderates effect of cumulative traumatic burden on risk for PTSD: A pilot study. Depress. Anxiety. May 23. [Epub ahead of print] PMID: 21608084
Uddin M, Galea S, Chang SC, Aiello AE, Wildman DE, de los Santos R, Koenen KC. (2011). Gene expression and methylation signatures of MAN2C1 are associated with PTSD. Dis. Markers. Jan 20:111-121. PMID: 21508515
Galea S, Uddin M, Koenen K. (2011). The Urban Environment and Mental Disorders: Epigenetic Links. Epigenetics. Apr 1:400-404. PMID: 21343702
Uddin M, Koenen KC, Aiello AE, Wildman DE, de los Santos R, Galea S. (2010) Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample. Psychol. Med. 14:1-11. PMID: 20836906
Koenen KC, Uddin M, Amstader A, Galea S. (2010) Incorporating the social environment in genotype environment interaction studies of mental disorders. Int. J. Clin. Pract. 64:1489-92. PMID: 20846196
Uddin M, Aiello AE, Wildman DE, Koenen KC, Pawelec G, de los Santos R, Goldmann E, Galea S. (2010) Epigenetic and immune function profiles associated with post-traumatic stress disorder. Proc. Natl. Acad. Sci. USA. 107:9470-5. PMID: 20439746.
Uddin M, Koenen KC, de los Santos R, Bakshis E, Aiello AE, Galea S. (2010) Gender differences in the genetic and environmental determinants of adolescent depression. Depress. Anxiety. 27:658-666. PMID: 20336806.