NEUROBIOLOGY OF DISEASE TRAINING PROGRAM
 
Faculty Member   Research Focus Major Faculty Techniques

Rodrigo Andrade
313-577-6006
randrade@med.wayne.edu


Electrophysiology and molecular biology of serotonergic and cholinergic synaptic transmission in the CNS;
Signaling by neuronal G protein coupled receptors;
Anatomy and physiology of the cerebral cortex.
Brain slice electrophysiology and live cell imaging including patch clamp recordings, confocal microscopy, and acute genetic manipulations of neurons implemented using particle mediated gene transfer and in utero electroporation techniques;
Optogenetic manipulations of neuronal activity and neuronal signaling.

Michael Bannon
313-993-4271
mbannon@med.wayne.edu


Molecular mechanisms controlling neural gene expression;
Molecular neuropathology of drug abuse and Parkinson’s disease.
Analysis of human postmortem tissue using cellular/molecular techniques;
Functional genomics and associated bioinformatics;
Intracerebral viral injections in animal models.

Diane Chugani
313-993-3847
dchugani@pet.wayne.edu





Autism Pet and MRI imaging

Donald DeGracia
313-577-6745
ddegraci@med.wayne.edu


Brain ischemic injury Whole animal physiology, histology and molecular biology

Aloke Dutta
313-577-1064
adutta@wayne.edu




CNS Drug Discovery and Characterization Medicinal Chemistry and Pharmacology

Alexander Gow
313-577-9401
agow@med.wayne.edu

Lab Information

Neurobiology of multiple sclerosis, Pelizaeus Merzbacher diseases and other CNS white matter diseases;
computational models of myelin; mechanisms of hearing loss;
neural processing in the auditory pathway; fate mapping of adult stem cells.
Knockout and transgenic mice;
Cre-lox and genetic switches;
mouse models of human disease;
light and electron microscopy;
mouse behavior: motor co-ordination, auditory and visual pathways;
electrophysiology;
functional genomics.

Zhou-Hua Pan
313-577-9830
zhpan@med.wayne.edu



Visual information processing in the retina;
Gene therapy for treating blinding retinal degeneration.
Molecular biology, electrophysiological recordings, immunocytochemistry, viral-based gene targeting, and animal behavior.

John Kamholz
313-577-0925
jkamholz@genetics.wayne.edu


Myelin Sheath, Multiple Sclerosis, Charcot-Marie Tooth Disease. Knockout Mice

Gregory Kapatos
313-577-5965
gkapato@med.wayne.edu


Cellular and molecular biology of monoamine neurotransmitter secreting neurons. Neurosciences

Donald Kuhn
313-577-9737
aa3071@wayne.edu



Molecular neurobiology of drug- and injury-induce damage to the brain All molecular, biochemical and cell biological approaches;
development of transgenic and knockout mice, fluorescence microscopy, HPLC

Jeffrey Loeb
313-577-9827
jloeb@med.wayne.edu

Lab Information

Developmental neuroscience;
molecular mechanisms in synapse formation;
neuregulins and neurotrophins in synaptic development;
functional genomic study of the pathogenesis of epilepsy and ALS.
Developmental biology, electroporation Knockout, transgenic mouse models of human disease Biochemistry, Cell Biology, Drug development Human tissue studies, electrophysiology of epilepsy Functional genomics and systems biology

Naftali Raz
313-577-2297
nraz@wayne.edu



Brain aging, its impact on cognitive performance, and modification of aging by vascular risk factors MRI, cognitive tests

Robert Skoff
313-577-1165
rskoff@med.wayne.edu


Disorders of brain white matter disease Tissue culture of neuroglial cells, molecular and cellular analyses of transgenic mice, electron microscopy

Derek Wildman
313-577-1253
dwildman@genetics.wayne.edu

Lab Information

Evolutionary genome analysis;
evolution of mammalian parturition.
Whole genome sequencing;
pyrosequencing;
functional genomics, computation.

 
       
 

 

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