Alexander Gow, PhD

Alexander Gow, PhD
Professor of Molecular Medicine and Genetics and of Pediatrics and of Neurology
Charles H. Gershenson Distinguished Fellow
Associate Director, Center for Molecular Medicine and Genetics
Elliman Building, Rm 2148
421 E. Canfield Avenue
Detroit, MI 48201
313-577-9401
agow@med.wayne.edu

Education

Queensland University, Australia, PhD, 1990

Research Focus

Role of the unfolded protein response in neurodegenerative diseases; molecular characterization and regulation of axoglial junction assembly in CNS myelin; molecular characterization of the claudin family of integral membrane tight junction proteins during development in brain, testis, and inner ear using transgenic and homologous recombination in embryonic stem cells; learning and memory deficits in neurodegenerative disease.

Recent Publications

Maheras KJ*, Peppi M, Ghoddoussi F, Galloway MP, Perrine SA, Gow A (2018) Axon Diameter-Dependent Saltatory Conduction Slowing Perturbs Behavior and Neurotransmitter Levels, Sci Rep, 8, 3798-3813.
 
Maheras KJ*, Pindolia K, Wolf B, Gow A (2017) Developmental Window of Sensorineural Deafness in Biotinidase-Deficient Mice, J Metabol Inherited Dis, doi: 10.1007/s10545-017-0049-z.
 
Southwood CM, Garshott DM, Richardson CR*, Seraji-Bozorgzad N, Fribley AM, Gow A (2017) Dimethyl Fumarate Ameliorates Myoclonus Stemming From Protein Misfolding In Oligodendrocytes, J Neurochem, DOI: 10.1111/jnc.14035. 
 
Yellbay B, Gow A, Jamil H (2017) Ranking Novel Regulatory Genes in Gene Expression Profiles using NetExpress, SAC 2017, pp.24-27; doi:10.1145/3019612.3021289.
 
Southwood CM, Fykkolodziej B*, Maheras KJ*, Garshott DM, Estill M*, Fribley AM, Gow A (2016) Overexpression of CHOP in myelinating cells does not confer a significant phenotype under normal or metabolic stress conditions, J Neurosci, 36, 6803-6819. 
 
Deninger AR, Breglio A, Maheras KJ*, LeDuc G, Cristiglio V, Deme B, Gow A, Kirschner DA (2015) Claudin-11 tight junctions in myelin are a barrier to diffusion and lack strong adhesive properties, Biophys J, 109, 1387-1397. doi:10.1016/j.bpj.2015.08.012