Heng Laboratory
@Wayne State University
Batoul Abdallah and Steven Horne
presented at the Midwest Graduate Research
Symposium
APR 20TH
Article published
in Cancer and
Metastasis Reviews
APR 19TH
Article published
in Cancer and
Metastasis Reviews
APR 18TH
Article published
in Cytogenetic
and Genome Research
APR 2ND
Article published
in Cytogenetic
and Genome Research
APR 2ND
Article published
in Systems
Biology in Reproductive Medicine
JAN 8TH
Article published
in Journal of
Cellular Physiology
SEP 27TH
"Why
imatinib remains an exception of cancer
research" by Steven D. Horne et al. has been
published by the Journal of Cellular Physiology
and is available online.
Abstract: The archetype driving the drug targeting approach to cancer therapy is the success of imatinib against chronic phase chronic myeloid leukemia (CML-CP). Molecular targeting success of this magnitude has yet to be repeated for most solid tumors. To answer why imatinib remains an exception of cancer research, we summarize key features and patterns of evolution that contrast CML-CP from prostate cancer, an example of a solid tumor that also shares a signature fusion gene....
Dr. Henry Heng
receives book deal from Springer
Abstract: The archetype driving the drug targeting approach to cancer therapy is the success of imatinib against chronic phase chronic myeloid leukemia (CML-CP). Molecular targeting success of this magnitude has yet to be repeated for most solid tumors. To answer why imatinib remains an exception of cancer research, we summarize key features and patterns of evolution that contrast CML-CP from prostate cancer, an example of a solid tumor that also shares a signature fusion gene....
Dr. Henry Heng
receives book deal from Springer
AUG 13TH
Dr.
Henry H.Q. Heng recently received a book deal
from Springer. His book, 4D-Genomics -
Genome Dynamics and Constraint in Evolution,
will be the first book to outline the new
genome-based genome research, point out new
direction in genome research, examine
three-dimensional interactions of the genome
over time, and lead readers to appreciate
previously ignored genome variation and its
important implications to evolution and
medicine.
Dr. Henry
Heng critiques current genetic theory,
discusses 4D-Genomics in CMMG Newsletter
Dr. Henry
Heng critiques current genetic theory,
discusses 4D-Genomics in CMMG Newsletter
JUL 24TH
Dr.
Henry Heng, Associate Professor of Molecular
Medicine and Genetics and of Pathology, is
taking a unique approach to genetic theory.
According to Heng, modern genetics might
need a complete overhaul to understand the
complex workings of the genome. Heng
says that geneticists have focused far too
much on individual genes and not enough on
the genome as a whole...
Dr. Henry H.Q. Heng receives
visiting professorship at Sichuan
University
Dr. Henry H.Q. Heng receives
visiting professorship at Sichuan
University
JUL 15TH
Dr.
Henry H.Q. Heng has received a visiting
professorship from the College of Life
Science at Sichuan University in Chengdu,
China.
Dr.
Henry H.Q. Heng appointed
co-Editor-in-Chief of Molecular
Cytogenetics
Dr.
Henry H.Q. Heng appointed
co-Editor-in-Chief of Molecular
Cytogenetics
JUN 12TH
Dr.
Henry H.Q. Heng was recently appointed
co-Editor-in-Chief of Molecular
Cytogenetics. He joins Thomas
Liehr (Institute of Human Genetics,
Germany) and Yuri Yurov (National
Research Center of Mental Health,
Russia) in leading the journal...
Batoul
Abdallah and Steven Horne presented
at the 2012 MARTS Research Symposium
Batoul Abdallah, Ph.D. Candidate,
and Steven Horne, Ph.D. student,
presented at the 3rd Annual Michigan
Alliance for Reproductive Technologies
and Science (MARTS) Research Symposium
on May 23, 2012. Batoul gave an oral
presentation titled 'Nonclonal
chromosomal aberrations as genomic
markers of ovarian cancer,' and
Steven's poster presentation was
titled 'Applying spectral karyotyping
to monitor ART-associated genome-level
alterations.' Both presentations were
well-received. Batoul and Steven were
invited to prepare manuscripts for an
upcoming special issue of Systems
Biology in Reproductive Medicine,
which is expected to be in print early
2013.
Dr. Heng seeks to
determine a link between genome
instability, chronic fatigue
syndrome
Batoul
Abdallah and Steven Horne presented
at the 2012 MARTS Research Symposium
MAY 23RD
Dr. Heng seeks to
determine a link between genome
instability, chronic fatigue
syndrome
MAR 30TH
A
national foundation has sought out a
Wayne State University researcher in
an effort to discover whether
overall genome instability rather
than a specific molecular mechanism
may cause chronic fatigue and immune
dysfunction syndrome (CFIDS)...
Dr. Henry H.Q. Heng
receives WSU School of Medicine
Faculty Research Excellence Award
Dr. Henry H.Q. Heng
receives WSU School of Medicine
Faculty Research Excellence Award
MAR 19TH
Dr.
Henry Heng was recently recognized
for receiving the Wayne State
University School of Medicine
Faculty Research Excellence Award
in 2010. This annual peer-judged
award is presented to exceptional
professors in each of the School's
basic science and clinical
departments...
Dr. Henry H.Q.
Heng awarded funding for
CFIDS/ME genomic research
Dr. Henry H.Q.
Heng awarded funding for
CFIDS/ME genomic research
DEC 1ST
Dr. Henry Heng
was recently awarded a $133,233
research grant from the National
CFIDS Foundation (Needham, MA),
in collaboration with The Nancy
Taylor Foundation for Chronic
Diseases (Tulsa, OK), aimed at
assessing disease damage in
patients with CFIDS/ME utilizing
molecular cytogenetic
technology...
Article
published in
the Encyclopedia
of Life Sciences
Article
published in
the Encyclopedia
of Life Sciences
OCT 17th
"Genetic and
epigenetic heterogeneity in
cancer," an invited article by
Joshua B. Stevens, Ph.D. et
al. has been published by the
Encyclopedia
of Life Sciences (eLS)
and is available online.
Abstract: Cancer is commonly viewed as a disease of the stepwise accumulation of gene mutations. However, genetic and epigenetic heterogeneity (GEH) is pervasive in cancer, playing a key role in promoting cancer progression...
Chapter
published in Advances in
Cancer Research
Abstract: Cancer is commonly viewed as a disease of the stepwise accumulation of gene mutations. However, genetic and epigenetic heterogeneity (GEH) is pervasive in cancer, playing a key role in promoting cancer progression...
Chapter
published in Advances in
Cancer Research
OCT 3RD
"Evolutionary
mechanisms and diversity in
cancer" by Dr. Henry H.Q.
Heng et al. has been
published in Advances in
Cancer Research and
is available online.
Abstract: The recently introduced genome theory of cancer evolution provides a new framework for evolutionary studies on cancer. In particular, the established relationship between the large number of individual molecular mechanisms and the general evolutionary mechanism of cancer calls upon a change in our strategies that have been based on the characterization of common cancer gene mutations and their defined pathways...
Sex
reduces genetic variation
Article
published in Cell Death
& Disease
Abstract: The recently introduced genome theory of cancer evolution provides a new framework for evolutionary studies on cancer. In particular, the established relationship between the large number of individual molecular mechanisms and the general evolutionary mechanism of cancer calls upon a change in our strategies that have been based on the characterization of common cancer gene mutations and their defined pathways...
Sex
reduces genetic variation
Jul 7th
Biology
textbooks maintain that
the main function of sex
is to promote genetic
diversity. But Henry Heng,
Ph.D., associate professor
in WSU's Center for
Molecular Medicine and
Genetics and Department of
Pathology, says that's not
the case...
Online discussions of this research:
Forumdesforums.com - Benard Dugué English translation (According to Google)
Shanghai Science News 7.26.2011
Beijing News 7.24.2011
DiscoverMagazine.com
ScienceDaily.com
Online discussions of this research:
Forumdesforums.com - Benard Dugué English translation (According to Google)
Shanghai Science News 7.26.2011
Beijing News 7.24.2011
DiscoverMagazine.com
ScienceDaily.com
Article
published in Cell Death
& Disease
Jun 30th
"Diverse
system stresses: common
mechanisms of chromosome
fragmentation" by Joshua
B. Stevens, Ph.D. et al.
has been published by the
Nature publication Cell Death
& Disease and
is available online.
Abstract: Chromosome fragmentation (C-Frag) is a newly identified MCD (mitotic cell death), distinct from apoptosis and MC (mitotic catastrophe). As different molecular mechanisms can induce C-Frag, we hypothesize that the general mechanism of its induction is a system response to cellular stress...
Article
published in Genomics
"Decoding the genome
beyond sequencing: The new
phase of genomic research"
by Dr. Henry H.Q. Heng et
al. has been published by
Genomics
and is available online.
Abstract: While our understanding of gene-based biology has greatly improved, it is clear that the function of the genome and most diseases cannot be fully explained by genes and other regulatory elements. Genes and the genome represent distinct levels of genetic organization with their own coding systems; Genes code parts like protein and RNA, but the genome codes the structure of genetic networks, which are defined by the whole set of genes, chromosomes and their topological interactions within a cell. Accordingly, the genetic code of DNA offers limited understanding of genome functions. In this perspective, we introduce the genome theory which calls for the departure of gene-centric genomic research...
Dr.
Henry H.Q. Heng awarded
funding for Gulf War
Illness genomic research
Dr. Henry Heng was
recently awarded a
$900,000 grant from the
U.S. Department of Defense
to study whether Gulf War
Illness (GWI) stems from
genomic instability, which
he believes is the common
link among GWI patients...
Abstract: Chromosome fragmentation (C-Frag) is a newly identified MCD (mitotic cell death), distinct from apoptosis and MC (mitotic catastrophe). As different molecular mechanisms can induce C-Frag, we hypothesize that the general mechanism of its induction is a system response to cellular stress...
Article
published in Genomics
May 27th
Abstract: While our understanding of gene-based biology has greatly improved, it is clear that the function of the genome and most diseases cannot be fully explained by genes and other regulatory elements. Genes and the genome represent distinct levels of genetic organization with their own coding systems; Genes code parts like protein and RNA, but the genome codes the structure of genetic networks, which are defined by the whole set of genes, chromosomes and their topological interactions within a cell. Accordingly, the genetic code of DNA offers limited understanding of genome functions. In this perspective, we introduce the genome theory which calls for the departure of gene-centric genomic research...
Dr.
Henry H.Q. Heng awarded
funding for Gulf War
Illness genomic research
Apr 11th