Leonard Lipovich, PhD

Leonard Lipovich, PhD
Associate Professor of Molecular Medicine and Genetics and of Neurology
Scott Hall, Rm 3208
540 E. Canfield Avenue
Detroit, MI 48201
313-577-9683
llipovich@med.wayne.edu

Education

University of Washington, PhD, 2003

Research Focus

A formidable conundrum of the post-genomic era is the abundance of eukaryotic transcripts which have limited interspecies conservation, do not encode proteins or small RNAs, and are devoid of known functional roles. My group integrates bioinformatics and experimentation to understand the evolutionary and functional genomics of these long non-protein-coding RNA (lncRNA) transcripts, with an emphasis on their roles in primate, and specifically human, phenotypic uniqueness.

Recent Publications

Johnsson P, Lipovich L, Grandér D, Morris KV. Evolutionary conservation of long non-coding RNAs; sequence, structure, function. Biochim Biophys Acta. 2014 Mar;1840(3):1063-71. doi: 10.1016/j.bbagen.2013.10.035. Epub 2013 Oct 27. Review. PubMed PMID: 24184936; PubMed Central PMCID: PMC3909678.

Romero R, Tarca AL, Chaemsaithong P, Miranda J, Chaiworapongsa T, Jia H, Hassan SS, Kalita CA, Cai J, Yeo L, Lipovich L. Transcriptome interrogation of human myometrium identifies differentially expressed sense-antisense pairs of protein-coding and long non-coding RNA genes in spontaneous labor at term. J Matern Fetal Neonatal Med. 2014 Jan 13. [Epub ahead of print] PubMed PMID: 24168098.

Bianchi S, Stimpson CD, Duka T, Larsen MD, Janssen WG, Collins Z, Bauernfeind AL, Schapiro SJ, Baze WB, McArthur MJ, Hopkins WD, Wildman DE, Lipovich L, Kuzawa CW, Jacobs B, Hof PR, Sherwood CC. Synaptogenesis and development of pyramidal neuron dendritic morphology in the chimpanzee neocortex resembles humans. Proc Natl Acad Sci U S A. 2013 Jun 18;110 Suppl 2:10395-401. doi:10.1073/pnas.1301224110. Epub 2013 Jun 10. PubMed PMID: 23754422; PubMed Central PMCID: PMC3690614.

Sterner KN, McGowen MR, Chugani HT, Tarca AL, Sherwood CC, Hof PR, Kuzawa CW, Boddy AM, Raaum RL, Weckle A, Lipovich L, Grossman LI, Uddin M, Goodman M, Wildman DE. Characterization of human cortical gene expression in relation to glucose utilization. Am J Hum Biol. 2013 May-Jun;25(3):418-30. doi: 10.1002/ajhb.22394. Epub 2013 Apr 4. PubMed PMID: 23559490.

Kraus P, Sivakamasundari V, Lim SL, Xing X, Lipovich L, Lufkin T. Making sense of Dlx1 antisense RNA. Dev Biol. 2013 Apr 15;376(2):224-35. doi: 10.1016/j.ydbio.2013.01.035. Epub 2013 Feb 8. PubMed PMID: 23415800.