Maik Hüttemann, PhD

Maik Hüttemann, PhD
Professor of Molecular Medicine and Genetics and of Biochemistry, Microbiology, and Immunology 
Division Director for Research, CMMG
Scott Hall, Rm 3214
540 E. Canfield Avenue
Detroit, MI 48201


Philipps University of Marburg, PhD, 1999

Research Focus

Our team studies mitochondrial function using genetic and biochemical approaches. We focus on two key components of the mitochondrial oxidative phosphorylation machinery, cytochrome c oxidase (COX) and the small electron carrier cytochrome c (Cytc). COX is the terminal enzyme of the mitochondrial respiratory chain, “burns” the oxygen we breathe to water, and pumps protons across the inner mitochondrial membrane generating the mitochondrial membrane potential, which is utilized by ATP synthase to produce energy in the form of ATP. Cytc has two distinct functions: it delivers electrons to COX, but it also participates in programmed cell death (apoptosis).

The overall goal of our work is to understand the regulation of COX and Cytc in normal and disease conditions. This regulation in turn affects energy production, free radical generation, and apoptosis. Research topics of the Hüttemann group under investigation include 1) cell signaling pathways that act on COX and Cytc, which pathways are often dysregulated in human diseases; 2) lung cancer; 3) neurodegenerative diseases; 4) gene regulation of COX subunit isoforms; and 5) novel strategies to boost mitochondrial function as a future treatment for diseases that manifest themselves in a lack of energy and increased cell death.

Recent Publications

To view a full list of Dr. Hüttemann's publications please follow this link. 

Kallpage H.A., Bazylianska V., Recanati M.A., Fite A., Liu J., Wan J., Mantena N., Malek M.H., Podgorski I., Heath E.I., Vaishnav A., Edwards B.F., Grossman L.I., Sanderson T.H., Lee I., Hüttemann M. (2018) Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis. FASEB J, in press.

Sanderson T.H., Wider, J.M., Lee, I., Reynolds, C.A., Liu, J., Lepore, B., Tousignant, R., Bukowski, M.J., Johnston, H., Fite, A., Raghunayakula, S., Kamholz, J., Grossman, L.I., Przyklenk, K., Hüttemann, M. (2018) Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury. Sci Rep. 8(1):3481.

Romero R, Erez O, Hüttemann M, Maymon E, Panaitescu B, Conde-Agudelo A, Pacora P, Yoon BH, Grossman LI. Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. American journal of obstetrics and gynecology. 2017; 217(3):282-302. PubMed [journal] PMID: 28619690

Sommer N, Hüttemann M, Pak O, Scheibe S, Knoepp F, Sinkler C, Malczyk M, Gierhardt M, Esfandiary A, Kraut S, Jonas F, Veith C, Aras S, Sydykov A, Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Circulation  research. 2017; 121(4):424-438. NIHMSID: NIHMS885641 PubMed [journal] PMID: 28620066, PMCID: PMC5544581

Jung YS, Najy AJ, Huang W, Sethi S, Snyder M, Sakr W, Dyson G, Hüttemann M, Lee I, Ali-Fehmi R, Franceschi S, Struijk L, Kim HE, Kato I, Kim HC. HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer. Oncotarget. 2017; 8(31):51530-51541. PubMed [journal] PMID: 28881665, PMCID: PMC5584266

Aras S, Arrabi H, Purandare N, Hüttemann M, Kamholz J, Züchner S, Grossman LI. Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration. Biochimica et biophysica acta. 2017; 1864(2):440-448. PubMed [journal] PMID: 27913209

Tyurina YY, Lou W, Qu F, Tyurin VA, Mohammadyani D, Liu J, Hüttemann M, Frasso MA, Wipf P, Bayir H, Greenberg ML, Kagan VE. Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells. ACS chemical biology. 2017; 12(1):265-281. NIHMSID: NIHMS854025 PubMed [journal] PMID: 27982579, PMCID: PMC5578713

Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, Sinkler C, Kapralov AA, Moraes CT, Sanderson TH, Stemmler TL, Grossman LI, Kagan VE, Brunzelle JS, Salomon AR, Edwards BF, Hüttemann M. Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE. The Journal of biological chemistry. 2017; 292(1):64-79. PubMed [journal] PMID: 27758862, PMCID: PMC5217700

Grossman LI, Purandare N, Arshad R, Gladyck S, Somayajulu M, Hüttemann M, Aras S. MNRR1, a Biorganellar Regulator of Mitochondria. Oxidative medicine and cellular  longevity. 2017; 2017:6739236. PubMed [journal] PMID: 28685009, PMCID: PMC5480048

Sinkler CA, Kalpage H, Shay J, Lee I, Malek MH, Grossman LI, Hüttemann M. Tissue- and Condition-Specific Isoforms of Mammalian Cytochrome Oxidase Subunits: From Function to Human Disease. Oxidative medicine and cellular longevity. 2017; 2017:1534056. PubMed [journal] PMID: 28593021, PMCID: PMC5448071