Maik Hüttemann, PhD
Scott Hall, Rm 3214
540 E. Canfield Avenue
Detroit, MI 48201
Philipps University of Marburg, PhD, 1999
Our team studies mitochondrial function using genetic and biochemical approaches. We focus on two key components of the mitochondrial oxidative phosphorylation machinery, cytochrome c oxidase (COX) and the small electron carrier cytochrome c (Cytc). COX is the terminal enzyme of the mitochondrial respiratory chain, “burns” the oxygen we breathe to water, and pumps protons across the inner mitochondrial membrane generating the mitochondrial membrane potential, which is utilized by ATP synthase to produce energy in the form of ATP. Cytc has two distinct functions: it delivers electrons to COX, but it also participates in programmed cell death (apoptosis).
The overall goal of our work is to understand the regulation of COX and Cytc in normal and disease conditions. This regulation in turn affects energy production, free radical generation, and apoptosis. Research topics of the Hüttemann group under investigation include 1) cell signaling pathways that act on COX and Cytc, which pathways are often dysregulated in human diseases; 2) lung cancer; 3) neurodegenerative diseases; 4) gene regulation of COX subunit isoforms; and 5) novel strategies to boost mitochondrial function as a future treatment for diseases that manifest themselves in a lack of energy and increased cell death.
Appikatla S, Bessert D, Lee I, Hüttemann M, Mullins C, Somayajulu-Nitu M, Yao F, Skoff RP. Insertion of proteolipid protein into oligodendrocyte mitochondria regulates extracellular pH and adenosine triphosphate. Glia. 2014 Mar;62(3):356-73. doi: 10.1002/glia.22591. Epub 2013 Dec 31. PubMed PMID: 24382809.
Lee H, Abe Y, Lee I, Shrivastav S, Crusan AP, Hüttemann M, Hopfer U, Felder RA, Asico LD, Armando I, Jose PA, Kopp JB. Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats. Kidney Int. 2014 Mar;85(3):561-9. doi: 10.1038/ki.2013.397. Epub 2013 Oct 16. PubMed PMID: 24132210; PubMed Central PMCID: PMC3943540.
Przyklenk K, Sanderson TH, Hüttemann M. Clinical benefits of remote ischemic preconditioning: new insights...And new questions. Circ Res. 2014 Feb 28;114(5):748-50. doi: 10.1161/CIRCRESAHA.114.303331. PubMed PMID: 24577960.
Elbaz HA, Lee I, Antwih DA, Liu J, Hüttemann M, Zielske SP. Epicatechin stimulates mitochondrial activity and selectively sensitizes cancer cells to radiation. PLoS One. 2014 Feb 6;9(2):e88322. doi: 10.1371/journal.pone.0088322. eCollection 2014. PubMed PMID: 24516636; PubMed Central PMCID: PMC3916420.