Siddhesh Aras, MBBS, PhD
Assistant Professor of Molecular Medicine and Genetics
Scott Hall, 3240
540, E.Canfield Street
Detroit, MI 48201
Oxidative phosphorylation, Role of mitochondria in infectious diseases, Transcriptional regulation of mitochondrial proteins.
Mitochondria are the power house of a cell. Oxidative phosphorylation (OxPhos) generates ATP that is used in various cellular processes. We are currently focussed on identifying and characterizing cellular regulators of OxPhos typically under conditions of cellular stress. We are also interested in understanding the signaling crosstalk between mitochondria and the nucleus where most of the mitochondrial proteins are transcribed.
A second project of interest is mitochondria in infectious diseases. We are currently focusing on viral infections. Viruses are obligatory intracellular microbes. Once in the cell, viral proteins either activate cell signaling pathways (e.g. TLRs) or directly affect a specific function (e.g. E1B-55K protein of adenovirus degrades cellular p53). We are interested in understanding how viral proteins usurp mitochondrial oxidative phosphorylation towards its own benefit, in order to better understand viral pathology and identify novel therapeutic targets.
Research FocusCell and Molecular Biology, Biochemistry, Microbiology