PhD program in  Molecular Biology and Genetics. more...
    
Concentration in Computational Biology
     Concentration in Neuroscience

MS in  Genetic Counselingmore...
Physician Medical Genetics training programs. more...


                               RECENT NEWSLETTERS

               
                     Winter 2013                                        Fall 2012

RESEARCH NEWS

 

ANNOUNCEMENTS


 

Source: Michael R. McGowen, Lawrence I. Grossman and Derek E. Wildman “Dolphin genome provides evidence for adaptive evolution of nervous system genes and a molecular rate slowdown” Proc Biol Sci. 2012 Sep 22;279(1743):3643-51. Epub 2012 Jun 27.






Source: Ze Zheng, Xiaohua Xu, Xuebao Zhang, Aixia Wang, Chunbin Zhang, Maik Hüttemann, Lawrence I. Grossman, Lung Chi Chen, Sanjay Rajagopalan, Qinghua Sun, Kezhong Zhang.  “Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model” J Hepatol. 2012 Aug 15. doi:pii: S0168-8278(12)00632-0. 10.1016/j.jhep.2012.08.009






Kraus P, Sivakamasundari V, Lim SL, Xing X, Lipovich L, Lufkin T. Making sense of Dlx1 antisense RNA.  Dev Biol. 2013 Apr 15;376(2):224-35. doi: 10.1016/j.ydbio.2013.01.035. Epub 2013 Feb 8.




Saporta MAC, Shy BR, Patzko A, Bai Y, Pennuto M, Ferri C, Tinelli E, Saveri P, Kirschner D, Crowther M, Southwood CM, Wu X, Gow A, Feltri ML, Wrabetz L, Shy ME (2012) MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth 1B Brain, 135:2032-2047. PMC3381724.





Recent Publications of Center Faculty Members

Kosir MA, Jia H, Ju D and Lipovich L (2013). Challenging paradigms: Long non-coding RNAs in breast ductal carcinoma in situ (DCIS).  Front. Genet. 4:50. doi: 10.3389/fgene.2013.00050.  More...

Kraus P, Sivakamasundari V, Lim SL, Xing X, Lipovich L, Lufkin T. Making sense of Dlx1 antisense RNA.  Dev Biol. 2013 Apr 15;376(2):224-35. doi: 10.1016/j.ydbio.2013.01.035. Epub 2013 Feb 8. More...

Lipovich L, Tarca AL, Cai J, Jia H, Chugani HT, Sterner KN, Grossman LI, Uddin M, Hof PR, Sherwood CC, Kuzawa CW, Goodman M, Wildman DE. Developmental Changes in the Transcriptome of Human Cerebral Cortex Tissue: Long Noncoding RNA Transcripts.  Cereb. Cortex (2013)  doi: 10.1093/cercor/bhs414.  More...

Southwood CM, Lipovich L, Gow A (2012) Tissue-Restricted Transcription from a Conserved Intragenic CpG Island in the Klf1 Gene. Biol Reprod, doi: 10.1095/ biolreprod.112.099879. PMC3509778.  More...

Hüttemann, M., Lee, I., Malek, M.H. (2012) (-)Epicatechin maintains endurance training adaptation in mice after 14 days of detraining. FASEB Journal, in press

Lipovich L, Johnson R, and Lin CY. MacroRNA underdogs in a microRNA world. (invited review article) Biochimica et Biophysica Acta 1799: 597-615, 2010. More....

Laing S, Wang G, Briazova T, Zhang C, Wang A, Zheng Z, Gow A, Chen AF, Rajagopalan S, Chen LC, Sun Q, Zhang K. Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. Am J Physiol Cell Physiol 299(4):C736-749, 2010. More....


News Archive

UPCOMING SEMINARS

  May 15, 2014

  Lynne Maquat, PhD
 
J. Lowell Orbison Endowed Chair and Professor, Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester
"'Alu'-strious effects on human mRNA metablism"
at noon in 3125 Scott Hall

  May 29, 2014

  Donald Conrad, PhD
Assistant Professor, Departments of Genetics and Pathology & Immunology, Washington University School of Medicine
"Genetic and genomic analyses of spermatogenic function"
at noon in 3125 Scott Hall

CENTER ANNOUNCEMENTS 

Leonard Lipovich, PhD, Associate Professor of Molecular Medicine and Genetics and of Neurology is a co-author of the paper "A Promoter Level Mammalian Expression Atlas," which will appear in the March 27, 2014 issue of Nature. The work provides the first ever quantitative definition of the complete set of human and mouse gene promoters at single-base resolution.  More...

Henry Heng, PhD, Associate Professor of Molecular Medicine and Genetics and of Pathology is featured in an April 2014 article of Genetic Engineering and Biotechnology News.  For many years, cancer has been viewed as a condition in which the progressive accumulation of recurrent mutations leads, in time, to the malignant phenotype. “However, sequencing data reveal that this is not the case,” says Dr. Heng.  More...

Alexander Gow, PhD, Professor of Molecular Medicine and Genetics and of Neurology and of Pediatrics has published in Brain Sciences fall 2013, titled 'Potential for Cell-Mediated Immune Responses in Mouse Models of Pelizaeus- Merzbacher Disease.' More...

Genetic Counseling Graduate Program 
Webinar Open House
Friday, October 25th, 2013 2:00-3:30 PM EDT:
Interested in becoming a genetic counselor?
Check the leaflet for more info.

The Center is pleased to announce that the Board of Governors of Wayne State University has approved three of our outstanding Faculty Members for promotion to the rank of Associate Professor with continuing tenure.  We applaud these Members for their dedication to research and education excellence, and congratulate them for achieving a significant milestone. The 2013 promotion and tenure recipients are:

Leonard Lipovich, Ph.D.
Associate Professor of Molecular Medicine & Genetics and of Neurology

Lobelia Samavati, M.D.
Associate Professor of Molecular Medicine & Genetics and of Internal Medicine

Kezhong Zhang, Ph.D. 
Associate Professor of Molecular Medicine & Genetics and of Immunology & Microbiology


Robert Skoff, Ph.D., Professor of Anatomy and Cell Biology, and Associate Member of CMMG, has been appointed a member of the Cellular and Molecular Biology of the Glia Study Section of the Center for Scientific Review of the National Institutes of Health. Dr. Skoff will serve through June 30, 2019.  More...

Leonard Lipovich, Ph.D.,  Assitant Professor of Molecular Medicine and Genetics has been selected to present his work on long non-coding ribonucleic acids at the Gordon Conference on Human Genetics and Genomics, set for July 7-12 at Bryant University, Smithfield, R.I.  More...

George Grunberger, M.D. has been elected vice president of the American Association of Clinical Endocrinologists; he will also serve on the association’s executive committee and the board of directors.  Dr. Grunberger is an affiliate member of the CMMG and former Director; in 2002 he founded the Grunberger Diabetes Institute in Bloomfield Hills, MI.   More...

Assistant Professor of Molecular Medicine and Genetics Leonard Lipovich, Ph.D., will present his lab’s work at the Cambridge Healthtech Institute’s Bio-IT World Conference and Expo 2013, speaking as part of the conference’s Track Nine, Drug Discovery and Informatics. Dr. Lipovich will present “Beyond ENCODE: Placing Long Non-Coding RNA Genes into Regulatory Networks for Therapeutics” in a 25-minute invited talk Thursday.  More...

Gerald Feldman, M.D., Ph.D., F.A.C.M.G., Professor of Molecular Medicine and Genetics, has been elected president-elect of the American College of Medical Genetics and Genomics. Dr. Feldman, director of Clinical Genetic Services, will serve as president-elect through March 2015, when he will become president of the college and hold that position through 2017. More...

Lobelia Samavati, M.D., F.C.C.P., Assistant Professor of Molecular Medicine and Genetics and Internal Medicine, and Director of the WSU Sarcoidosis/Interstitial Lung Disease Center, will use a $389,681 grant for her study, “The Role and Regulation of MKP-1 in Sarcoidosis.” The grant from the National Heart, Lung and Blood Institute is part of a larger overall $1,906,944 NIH grant.  More...

Interested in becoming a genetic counselor? Visit our open house to learn more about the Wayne State University Genetic Counseling Graduate Program.

Recent research conducted by Center Assistant Professor Dr. Kezhong Zhang, has discovered why people living in congested, urban environments are at greater risk of developing metabolic disease.  The study focuses on air particulate matter, called PM 2.5, and its affects on the liver.  More information is available here.

Wayne State's Systems Biology of Epilepsy Project, led by Jeffrey Loeb, MD, PhD, Associate Director of the Center for Molecular Medicine and Genetics and Professor of Neurology, has released three new, published studies that could have a major impact on the treatment of epilepsy.  Find out more here.

Gregory Kapatos, PhD, Professor of Molecular Medicine and Genetics and of Pharmacology and Leonard Lipovich, PhD, Assistant Professor of Molecular Medicine and Genetics and of Neurology have received the 2012 College Teaching Award in the School of Medicine.

Michael Tainsky, PhD, Professor of Oncology and of Molecular Medicine and Genetics and Derek Wildman, PhD, Associate Professor of Molecular Medicine and Genetics and of Obstetrics and Gynecology have received the 2012 Research Excellence Award in the School of Medicine.

The Center would like to welcome Dr. Samiran Ghosh.  Dr. Ghosh, a biostatistician, will be Assistant Professor of Family Medicine and Public Health Sciences and of Molecular Medicine and Genetics. He comes from the Stony Brook University School of Medicine in New York, where he worked  on several depression-based projects. He has also published a book titled, "Bayesian Modeling in Bioinformatics."

The Center would like to introduce Erin Carmany, MSCGC, who will be Assistant Professor of Molecular Medicine and Genetics as well as Associate Director of the Genetic Counseling graduate program.  Ms. Carmany has served in the graduate program since 2005 as a clinical instructor.

Dr. Leonard Lipovich, Assistant Professor of Genetics and Molecular Medicine and of Neurology, is determined to prove genetic material once seen as "junk" to be of clinical value.  Dr. Lipovich's lab has already contributed several articles to the Encyclopedia of DNA (ENCODE), an international collaborative effort that is the follow-up to the Human Genome Project.  This work is putting Wayne State University at the forefront of genome analysis, and bringing it alongside high-profile researcher groups in the United States, and Japan. 

The Center welcomes Dr. Roger Pique-Regi as its newest faculty member.  Dr. Pique-Regi is the new Assistant Professor of Molecular Medicine and Genetics and also with the Department of Clinical and Translational Sciences.  His lab focuses on the topic of genetic instability, specifically finding the DNA sequences responcible for gene expression and how genetic instability can lead to disease.  His lab also distributes two software packages, CENTIPEDE and GADA, programs used for genetic analysis. 

Dr. Maik Hüttemann, who is Associate Professor of Molecular Medicine and Genetics and also of Biochemistry and Molecular Biology, has been selected to receive a 2012 President's Award for Excellence in Teaching.  Dr. Hüttemann will be presented with the award at the Wayne State University Academic Recognition Ceremony held April 26 at the McGregor Memorial Conference Center, where he will receive a citation and a cash award of $2,500.  

Dr. Jeffrey A. Loeb, Professor of Neurology and of Molecular Medicine and Genetics, and Associate Director of the Center, has been selected to receive the 2012 Charles H. Gershenson Distinguished Faculty Fellowship.  Dr. Loeb will receive the Fellowship on July 1st, which includes a total of $13,000 in funds for the next two years. 

Monica Uddin, PhD, Assistant Professor of Molecular Medicine and Genetics and of Psychiatry and Behavioral Neurosciences, has been awarded the 2012 Eli Robins, Samuel Guze award for early career promise by the American Psychopathological Association. More...

News Archive

 

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