Wayne State University School of Medicine

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Markku Kurkinen, professor (also with pathology); Ph.D.,1979, Helsinki, Finland. Extracellular matrix; metalloproteinases; gene regulation; development; disease.

Publications 1996

Sawai, T., Uzuki, M., Harris, E.D., Jr., Kurkinen, M., Trelstad, R.L. and Hayashi, M. (1996) In situ hybridization of stromelysin mRNA in the synovial biopsies from rheumatoid arthritis.Tohoku J. Exp. Med.178, 315-330

Benbow, U., Buttice, G., Nagase, H. and Kurkinen, M. (1996) Characterization of the 46-kDa intermediates of matrix metalloproteinase-3 (stromelysin-1) obtained by site-directed mutation of phenylalanine-83. J. Biol. Chem. 271, 10715-10722

Ye, S., Eriksson, P., Hamsten, A., Kurkinen, M., Humpries, S.E. and Henney, A.M. (1996) Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. J. Biol. Chem. 271, 13055-13061

Yang, M., Hayashi, K., Hayashi, M., Fujii, J.T. and Kurkinen, M. (1996) Cloning and developmental expression of a membrane type-matrix metalloproteinase from chicken. J. Biol. Chem. 271, 25548-25554

Buttice, G., Duterque-Coquillaud, M., Basuyaux, J.P., Carrere, S., Kurkinen, M. and Stehelin, D. (1996) Erg, an Ets-family member, differentially regulates human collagenase1 (MMP1) and stromelysin1 (MMP3) gene expression by physically interacting with the Fos/Jun complex. Oncogene 13, 2297-2306

Gervasi, D.C., Raz, A., Dehem, M., Yang, M., Kurkinen, M. and Fridman, R. (1996) Carbohydrate-mediated regulation of matrix metalloproteinase-2 activation in normal human fibroblasts and fibrosarcoma cells. Biochem. Biophys. Res. Commun. 228, 530-538


Yang, M., Murray, M.T. and Kurkinen, M. (1997) A novel matrix metalloproteinase gene (XMMP) encoding vitronectin-like motifs is transiently expressed in Xenopus laevis early embryo development. J. Biol. Chem. 272, 13527-13533


Yang, M. and Kurkinen, M. (1998) Cloning and developmental regulation of tissue inhibitor of metalloproteinases-3 (TIMP3) in Xenopus laevis early embryos. Gene 211, 95-100

Yang, M. and Kurkinen, M. (1998) Cloning and characterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo fibroblasts. CMMP, Xenopus XMMP and human MMP19 have a conserved unique cysteine in the catalytic domain.J. Biol. Chem. 273, 17893-17900


Jayaraman, G., Srinivas, R., Duggan, C., Ferreira, E., Swaminathan, S., Somasundaram. K., Williams, J., Hauser, C., Kurkinen, M., Dhar, R., Weitzman, S., Buttice, G. and Thimmapaya, B. (1999) p300/CBP interactions with Ets-1 and Ets-2 in the transcriptional activation of the human stromelysin promoter. J Biol. Chem. 274, 17342-17352

Olsson, M., Ekblom, M., Fecker, L., Kurkinen, M. and Ekblom, P. (1999) cDNA cloning and embryonic expression of mouse nuclear pore membrane glycoprotein 210 mRNA. Kidney Int. 56, 827-838

October 7, 1999



Markku Kurkinen Lab

Acknowledgements and Notes

Address for correspondence:
Markku Kurkinen
Wayne State University School of Medicine
Center for Molecular Medicine and Genetics
5125 Biological Sciences Building
5047 Gullen Mall
Detroit, MI 48202