Christopher Sinkler


  • Graduated with a Bachelor of Science in Biochemistry and Molecular Biology from Michigan State University in 2009
  • Currently a seventh year student in the PhD program

Research Interests

  • Advisor: Maik Huttemann, PhD
  • My interest in the program was piqued by both the wide array of opportunities available and numerous fields of study relating to molecular biology, as well as a fondness for the city of Detroit. The Center of Molecular Medicine and Genetics has proven to be the ideal grounds for expanding my knowledge of the field and further refining my interests in future research endeavors. I am currently a member of Dr. Maik Huttemann's lab, currently involved in two projects: a novel sample-driven assay reporter system for a lung cancer marker, as well as the use of light treatment in manipulation of mitochondrial enzymes and their involvement in ischemia/reperfusion injury. In addition, we are pursuing exciting work revolving around manipulating lung-specific mitochondrial enzymes to elucidate how mitochondria may regulate ventilation/perfusion ratios at the lung interface, and possible mechanisms for hypoxic pulmonary vasoconstriction.

Selected Publications

Ruckle ME, Burgoon LD, Lawrence LA, Sinkler CA, Larkin RM. "Plastids are major regulators of light signaling in Arabidopsis." Plant Physiol. 2012 May.

Huttemann M, Helling S, Sanderson TH, Sinkler C, Samavati L, Mahapatra G, Varughese A, Lu G, Liu J, Ramzan R, Vogt S, Grossman LI, Doan JW, Marcus K, Lee I. "Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation." Biochim Biophys Acta, 2011 Jul 13.